The Pathology of Biliary Tract Carcinoma (BTC)
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".
Deadline for manuscript submissions: 20 May 2025 | Viewed by 72
Special Issue Editor
Special Issue Information
Dear Colleagues,
There are several controversial issues within the pathology of biliary tract carcinoma. While two subtypes of intrahepatic cholangiocarcinoma (small duct and large duct type) were proposed in the WHO’s 2019 tumor classification, more studies and information are necessary to expand our understanding of their pathologic classification and characterization and the development of carcinoma. Several preinvasive lesions, such as IPNB and IOPN and ITPN and high-grade BilIN in the large bile ducts and pyloric gland adenoma, high-grade BilIN and ICPN in the gallbladder, were proposed in the WHO’s 2019 tumor classification; however, more pathological and genetic/molecular studies are needed to help us to understand these lesions. More studies are mandatory for the clarification of the precursors to small duct intrahepatic cholangiocarcinoma. The peribiliary glands and the interface between hepatocytes and bile ductules are two anatomical regions that contain hepatic/biliary/enteric stem cells, and more pathologic studies and reviews are mandatory to reveal the neoplasms that arise in these stem cell niches. We welcome both original studies and reviews on these controversial pathological fields in this Special Issue.
Dr. Yasuni Nakanuma
Guest Editor
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Keywords
- bile duct
- gallbladder
- bile ductules
- precursors
- preinvasive neoplasm
- stem/progenitor cells
- cholangiocar-cinoma
- gallbladder carcinoma
- pathology
