Advance in Hepatopancretobiliary Cancers: A Themed Issue in Honor of Prof. Dr. Timothy M. Pawlik

A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: 30 December 2024 | Viewed by 975

Special Issue Editor


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Guest Editor
Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova, 35122 Padova, Italy
Interests: gastrointestinal surgery; surgical oncology; hepatobiliary; neuroendocrine; gastric

Special Issue Information

Dear Colleagues,

Prof. Timothy M. Pawlik is a distinguished surgical oncologist, renowned for his expertise in treating patients with liver, gallbladder, pancreatic, and neuroendocrine tumors. Currently serving as the Surgeon-in-Chief at The Ohio State University Wexner Medical Center, Prof. Pawlik brings a wealth of experience and compassion to his practice. In addition to his medical degree, Master of Public Health, and PhD, he holds a master’s degree in theological studies from Harvard Divinity School. Prof. Pawlik occupies the prestigious Urban Meyer III and Shelley Meyer Chair for Cancer Research, reflecting his commitment to advancing the field of oncology. His approach to cancer care is deeply personal; Prof. Pawlik strives to deliver the highest quality care through a multidisciplinary approach that emphasizes shared decision making, empowerment, and compassion for patients, their families, and the cancer treatment team. A prolific researcher, Prof. Pawlik has lead hundreds of published studies. As a member of the Cancer Control Program at the OSUCCC – James, his research focuses on understanding the factors associated with prognosis and staging in hepatopancreatobiliary cancers. He also investigates patient–physician communication, patient engagement, and perceptions surrounding the goals of cancer care. Prof. Pawlik's contributions to the field are extensive, with over 1800 articles in leading scientific journals, more than 100 book chapters, and 16 edited surgical textbooks to his name. Prof. Pawlik completed his graduate studies at the John Hopkins University Bloomberg School of Public Health, his medical degree at Tufts University School of Medicine, his residency in General Surgery at the University of Michigan Hospitals, and his fellowship in Surgical Oncology at the University of Texas MD Anderson Cancer Center. In recognition of Prof. Pawlik's remarkable contributions to surgical oncology and hepatopancreatobiliary cancer research, and as a mentee who has benefited from his guidance and mentorship, it is my honor to serve as a Guest Editor for this Special Issue dedicated to his legacy. I invite all colleagues, collaborators, and former mentees to contribute their research to this Special Issue, highlighting the profound impact of Prof. Pawlik's work within the field of oncology.

Dr. Gaya Spolverato
Guest Editor

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Keywords

  • hepatobiliary surgery
  • pancreatic cancer
  • liver surgery
  • neuroendocrine tumors
  • surgical oncology
  • cancer prognosis

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Published Papers (1 paper)

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Research

13 pages, 1683 KiB  
Article
Influence of Perineural (Pn), Lymphangio (L) and Vascular (V) Invasion on Survival after Resection of Perihilar Cholangiocarcinoma
by Rabea Margies, Lisa-Katharina Gröger, Beate K. Straub, Fabian Bartsch and Hauke Lang
Cancers 2024, 16(20), 3463; https://doi.org/10.3390/cancers16203463 - 12 Oct 2024
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Abstract
Introduction: Perihilar cholangiocarcinoma is a rare malignancy of the biliary tract, for which surgery remains the treatment of choice. However, even after radical resection, the prognosis is poor. In addition to tumor size, depth of invasion and nodal/metastatic status, the TNM classification includes [...] Read more.
Introduction: Perihilar cholangiocarcinoma is a rare malignancy of the biliary tract, for which surgery remains the treatment of choice. However, even after radical resection, the prognosis is poor. In addition to tumor size, depth of invasion and nodal/metastatic status, the TNM classification includes additional parameters such as perineural (Pn), lymphangio (L) and vascular (V) invasion. The prognostic impact of these factors is not yet fully understood. The aim of this study was to investigate the influence of these parameters on overall survival after resection of perihilar cholangiocarcinoma. Material and Methods: Data from all patients who underwent surgical exploration for perihilar cholangiocarcinoma between January 2013 and December 2023 were included into an institutional database. The impact of perineural, lymphangio and vascular invasion on overall survival was analyzed. Results: Over the 11-year period, a total of 214 patients underwent surgical exploration for perihilar cholangiocarcinoma. Curative intended resection was possible in 168 patients (78.5%). Perineural invasion, lymphangio invasion and vascular invasion were present in 79.2%, in 17.3% and in 14.3% of patients, respectively. Cross tabulation revealed a significant association between the presence of L1 and V1 (p = 0.006). There was also a significant association of Pn1, L1, and V1 with R-status (p = 0.010; p = 0.006 and p ≤ 0.001). While V1 was associated with significantly worse overall survival across the entire cohort, Pn1 alone showed only a tendency towards worse overall survival without reaching statistical significance. In Bismuth type IV, both L1 and V1, but not Pn1, were significantly associated with worse overall survival (p = 0.001; p = 0.017 and p = 0.065). Conclusions: Perineural invasion is very common in perihilar cholangiocarcinoma. Although Pn1 was associated with a tendency toward worse survival, it did not reach statistical significance. In contrast, vascular invasion significantly worsened overall survival in the entire cohort, and lymphangio invasion was linked to worse overall survival in Bismuth type IV tumors. The combination of perineural invasion with positivity of more than one additional factor (either L or V) was also associated with worse overall survival. In patients with Bismuth type IV, these pathological markers appeared to have even greater prognostic relevance. Full article
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