Advances in Antitumor Molecular-Targeted Agents of Urological Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 4067

Special Issue Editors


E-Mail Website
Guest Editor
Department of Oncology and Haematology, Azienda Ospedaliero-Universitaria of Modena, 41124 Modena, Italy
Interests: urological and gynecological cancers

E-Mail Website
Guest Editor
Department of Oncology and Haematology, Azienda Ospedaliero-Universitaria of Modena, 41124 Modena, Italy
Interests: urological and gynecological cancers

Special Issue Information

Dear Colleagues,

According to tumor malignancy statistics, the occurrence of urological cancers is continuously increasing in Western countries; this is mainly due to the increased life expectancy in these geographic areas, but other factors also contribute to this growth.

An understanding of dysregulated pathways and the identification of potential biomarkers for the treatment of urological cancers have facilitated the identification of new targets and pathways for novel-targeted therapies, including immunomodulatory agents and agents that target angiogenesis, growth factor receptors, and epigenetic pathways. The aim of this Special Issue is to present recent advances in antitumor molecular-targeted agents in prostate, kidney, bladder, and testicular cancer, and to present clinical evidence of their use, whether alone or in combination.

Dr. Maria Giuseppa Vitale
Dr. Roberto Sabbatini
Guest Editors

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Keywords

  • immunotherapy
  • targeted therapy
  • urological cancers
  • angiogenesis
  • prostate, kidney, bladder, and testicular cancer

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Published Papers (2 papers)

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Research

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12 pages, 927 KiB  
Article
Advanced Non-Clear Cell Renal Cell Carcinoma Treatments and Survival: A Real-World Single-Centre Experience
by Davide Bimbatti, Francesco Pierantoni, Eleonora Lai, Melissa Ballestrin, Nicolò Cavasin, Elisa Erbetta, Chiara De Toni, Umberto Basso and Marco Maruzzo
Cancers 2023, 15(17), 4353; https://doi.org/10.3390/cancers15174353 - 31 Aug 2023
Cited by 2 | Viewed by 1312
Abstract
Background: Non-clear cell renal cell carcinoma (nccRCC) is a heterogeneous group of cancer. Treatment recommendations are extrapolated from ccRCC and lack solid evidence. Here, we review advanced nccRCC patients treated at our institute. Patients and methods: We collected retrospective data on all advanced [...] Read more.
Background: Non-clear cell renal cell carcinoma (nccRCC) is a heterogeneous group of cancer. Treatment recommendations are extrapolated from ccRCC and lack solid evidence. Here, we review advanced nccRCC patients treated at our institute. Patients and methods: We collected retrospective data on all advanced nccRCC pts treated at the Istituto Oncologico Veneto from January 2008. We compared overall response rate (ORR), progression free survival (PFS) and overall survival (OS) according to histological subtypes and type of systemic treatments. Kaplan-Meier method, log-rank test and Cox regression were used to estimate and compare PFS and OS. Results: Of 1370 RCC patients, 289 had a diagnosis of nccRCC and 121 were eligible for the analysis. Fifty-three pts showed papillary histology (pRCC), 15 chromophobe; 37 unclassified RCC (NOS-RCC), 16 other histologies. Pts with chromophobe and other hystologies showed poorer survival rates compared to pRCC and NOS-RCC (mOS 10.7 vs. 20.7 vs. 30.7, p = 0.34). Pts treated with combination regimens achieved a better OS (30.7 vs. 13.7, p = 0.10), PFS (12.7 vs. 6.4, p = 0.10) and ORR (42.4% vs. 13.9%, p = 0.002) than those treated with monotherapy. IMDC and Meet-URO score retained their prognostic value. Conclusion: Our retrospective real-life cohort of advanced nccRCC patients shows that immunotherapy-based combinations could improve ORR, PFS and OS compared to TKI monotherapy. Prospective trials for nccRCC patients utilizing novel therapies are ongoing and their results eagerly awaited. Full article
(This article belongs to the Special Issue Advances in Antitumor Molecular-Targeted Agents of Urological Cancers)
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Review

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17 pages, 933 KiB  
Review
De Novo Metastatic Prostate Cancer: Are We Moving toward a Personalized Treatment?
by Claudia Piombino, Marco Oltrecolli, Elena Tonni, Marta Pirola, Rossana Matranga, Cinza Baldessari, Stefania Pipitone, Massimo Dominici, Roberto Sabbatini and Maria Giuseppa Vitale
Cancers 2023, 15(20), 4945; https://doi.org/10.3390/cancers15204945 - 11 Oct 2023
Cited by 4 | Viewed by 2301
Abstract
De novo metastatic hormone-sensitive PC (mHSPC) accounts for 5–10% of all prostate cancer (PC) diagnoses but it is responsible for nearly 50% of PC-related deaths. Since 2015, the prognosis of mHSPC has slightly improved thanks to the introduction of new hormonal agents and [...] Read more.
De novo metastatic hormone-sensitive PC (mHSPC) accounts for 5–10% of all prostate cancer (PC) diagnoses but it is responsible for nearly 50% of PC-related deaths. Since 2015, the prognosis of mHSPC has slightly improved thanks to the introduction of new hormonal agents and chemotherapy combined with androgen deprivation therapy from the first-line setting. This review describes the current therapeutic opportunities for de novo mHSPC, focusing on potential molecular biomarkers identified in the main clinical trials that have modified the standard of care, the genomic features of de novo mHSPC, and the principal ongoing trials that are investigating new therapeutic approaches and the efficacy of a biomarker-guided treatment in this setting. The road toward personalized treatment for de novo mHSPC is still long, considering that the randomized clinical trials, which have furnished the basis of the current therapeutic options, stratified patients according to clinical criteria that did not necessarily reflect the biological rationale of the chosen therapy. The role of transcriptomic profiling of mHSPC as a predictive biomarker requires further validation, and it remains to be ascertained how the genomic variants detected in mHSPC, which are regarded as predictive in the castration-resistant disease, can be exploited in the mHSPC setting. Full article
(This article belongs to the Special Issue Advances in Antitumor Molecular-Targeted Agents of Urological Cancers)
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