Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) in Cancer Therapy
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 31 July 2025 | Viewed by 1218
Special Issue Editor
Interests: gastrointestinal, colorectal, and pancreatic surgery; mini-invasive surgery; peritoneal metastasis; cytoreductive surgery; PIPAC; HIPEC
Special Issue Information
Dear Colleagues,
You are cordially invited to contribute to the Special Issue "Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) for Cancer Therapy".
Peritoneal metastases (PMs) are common in the advanced stages of many intra-abdominal malignancies. Unfortunately, treatment options for unresectable PMs are limited, and the standard treatment is palliative systemic chemotherapy, with unsatisfactory results.
PIPAC is an innovative treatment modality for unresectable peritoneal metastasis ensuring better distribution of the aerosol-chemotherapy into the abdominal cavity and deeper tissues and nodules drug penetration. Since its first description in 2011, PIPAC has proven to be a feasible and safe procedure. Due to its mini-invasive nature and safe profile, it seems a promising tool for implementing the comprehensive treatment of patients with peritoneal metastasis.
Ongoing research is exploring new drugs for intraperitoneal administration, the safety of combining use with systemic chemotherapy, and the efficacy of PIPAC compared with the standard treatment.
In this Special Issue, we aim to emphasize patient selection criteria, the treatment response assessment, the efficacy outcomes, the economic costs of the procedure, the pharmacokinetic results of the aerosol chemotherapy, and the emerging topic of PIPAC as neoadjuvant treatment.
Original research articles and reviews are welcome.
We look forward to receiving your contributions.
Dr. Andrea Di Giorgio
Guest Editor
Manuscript Submission Information
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Keywords
- PIPAC
- intraperitoneal chemotherapy
- aerosol chemotherapy
- peritoneal metastasis
- neoadjuvant
- bidirectional treatment
- patient selection
- peritoneal carcinomatosis
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