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Novel Developments in Invasive Lobular Breast Cancer: Diagnosis, Prognosis and Therapy (2nd Edition)

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Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue, “Novel Developments in Invasive Lobular Breast Cancer: Diagnosis, Prognosis and Therapy” (https://www.mdpi.com/journal/cancers/special_issues/60X8Y1HI7F).

Invasive lobular carcinoma is the most common special subtype of invasive breast carcinoma. In addition to its specific morphology, it has different clinical, imaging, molecular, and treatment features compared to invasive breast carcinoma of no special type, as well as other special histologic subtypes.

Recent developments in this field include the recognition of novel subtypes.

We invite you to contribute articles to this Special Issue, which will complement existing knowledge concerning the diagnosis, prognosis, and treatment of invasive lobular breast cancer. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: clinical, imaging, pathologic, molecular, and treatment features of invasive lobular carcinoma.

We look forward to receiving your contributions.

Dr. Lubna Khaldi
Dr. Nektarios Koufopoulos
Guest Editors

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12 pages, 1979 KB

Open AccessArticle

The Rationale for Postoperative MRI Surveillance in Lobular Breast Cancer

by Lora Grbanović, Lucija Kovačević, Ana Smolić and Maja Prutki

Cancers 2026, 18(5), 776; https://doi.org/10.3390/cancers18050776 - 28 Feb 2026

Viewed by 450

Abstract

Background/Objectives: Postoperative breast cancer imaging follow-up primarily relies on annual mammography, while magnetic resonance imaging is reserved for selected cases. Invasive lobular carcinoma has growth characteristics that can limit detection on conventional imaging and may influence recurrence patterns. This study aimed to determine whether histological type can help guide postoperative magnetic resonance imaging follow-up. Secondary objectives were to assess inter-reader agreement and evaluate timing of new breast malignancies in relation to tumor features. Methods: This retrospective, single-center study included patients with invasive breast carcinoma diagnosed during 2015 and 2016 who underwent surgery, had pre-treatment magnetic resonance imaging, at least one postoperative magnetic resonance imaging within five years, and a minimum follow-up of seven years. Clinical, pathological, and imaging data were collected. New breast malignancies included both local recurrences and second primary tumors. Two radiologists independently reviewed postoperative magnetic resonance imaging examinations in patients, and inter-reader agreement was assessed using Cohen’s kappa coefficient. Results: Seventy-seven patients with 80 tumors were included. Six patients (8%) developed a new breast malignancy. New malignancies were more common in patients with invasive lobular carcinoma (p = 0.04). Magnetic resonance imaging detected all new malignancies in patients with primary invasive lobular carcinoma, whereas mammography missed two of three cases. New breast malignancies were classified as early (within 5 years of diagnosis and initial treatment) or late (at or after 5 years); most occurred within five years, with one late occurrence at 5.6 years. Inter-reader agreement for both magnetic resonance imaging and mammographic detection showed complete concordance (κ = 1.00). Conclusions: Patients with primary invasive lobular carcinoma had a higher rate of new breast malignancies, and postoperative magnetic resonance imaging detected new malignancies missed by mammography. These findings suggest that tumor histology may be relevant when considering postoperative imaging and that patients with invasive lobular carcinoma may benefit from magnetic resonance imaging follow-up. Full article

(This article belongs to the Special Issue Novel Developments in Invasive Lobular Breast Cancer: Diagnosis, Prognosis and Therapy (2nd Edition))

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