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Cancers
Special Issues
Patient-Centered Outcomes of Colorectal Cancer Surgery
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Patient-Centered Outcomes of Colorectal Cancer Surgery

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 1665

Special Issue Editors

Dr. Ira L. Leeds

E-Mail Website
Guest Editor
Yale School of Medicine, New Haven, CT, USA
Interests: colorectal cancer; quality of life; surgical outcomes; shared decision-making
Dr. Zhaomin Xu

E-Mail Website
Guest Editor
1. Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA
2. Department of Colorectal Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA
Interests: multidisciplinary teams; quality of life; colorectal surgery

Special Issue Information

Dear Colleagues,

The approaches to treating, curing, and palliating colorectal cancer have exponentially grown in the last two decades. Recent clinical trials continue to challenge and revise our profession’s understanding of the “best” oncologic therapy. However, a comprehensive understanding of the quality of life impact and formal ways of assessing it remain under emphasized.

The purpose of this Special Issue will be to highlight promising efforts to explore patient-centered outcomes of colorectal cancer surgery and the adjunctive therapies. Priority research areas include the following: comparative quality of life outcomes obtained by therapeutic approaches or sequencing, late effects of colorectal cancer surgery, quality of life considerations in patients with early-onset colorectal cancer, and novel approaches to shared decision-making. In addition to conventional studies of interest such as observational studies, clinical trials, and systematic reviews, we are also interested in highlighting novel research methods such as patient- and provider-oriented qualitative interviewing, mixed methods, healthcare economic modeling, and simulation-based models.

Dr. Ira L. Leeds
Dr. Zhaomin Xu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • colorectal cancer
  • quality of life
  • postoperative outcomes

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Published Papers (2 papers)

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Review

22 pages, 593 KiB  
Review
Journey through the Decades: The Evolution in Treatment and Shared Decision Making for Locally Advanced Rectal Cancer
by Racquel S. Gaetani, Keren Ladin and Jonathan S. Abelson
Cancers 2024, 16(16), 2807; https://doi.org/10.3390/cancers16162807 - 9 Aug 2024
Viewed by 552
Abstract
The management of locally advanced rectal cancer has undergone significant transformations over the decades and optimal treatment approaches continue to evolve. There have been numerous advances in surgery, chemotherapy, and radiation therapy from the first description of the abdominoperineal resection in 1908, timing [...] Read more.
The management of locally advanced rectal cancer has undergone significant transformations over the decades and optimal treatment approaches continue to evolve. There have been numerous advances in surgery, chemotherapy, and radiation therapy from the first description of the abdominoperineal resection in 1908, timing of chemotherapy and radiation therapy in the late 20th and early 21st century, and most recently, the introduction of organ preservation or nonoperative management in 2004. Alongside these advancements, the concept of shared decision making in medicine has evolved, prompting a focus on patient-centered care. This evolution in practice has been fueled by a growing recognition of the importance of patient autonomy and the alignment of treatment options with patients’ values and preferences. With the growing number of possible treatment options, variability in patient counseling exists, highlighting the need for a standardized approach to shared decision making in locally advanced rectal cancer. This narrative review will describe the evolution of treatment options of locally advanced rectal cancer as well as the concept of shared decision making and decision aids, and will introduce a decision aid for patients with locally advanced rectal cancer who have achieved a complete clinical response and are eligible for watch and wait. Full article
(This article belongs to the Special Issue Patient-Centered Outcomes of Colorectal Cancer Surgery)
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11 pages, 228 KiB  
Review
Low Anterior Resection Syndrome following Restorative Proctectomy for Rectal Cancer: Can the Surgeon Have Any Meaningful Impact?
by Richard C. Garfinkle and Nicholas P. McKenna
Cancers 2024, 16(13), 2307; https://doi.org/10.3390/cancers16132307 - 24 Jun 2024
Viewed by 657
Abstract
Postoperative bowel dysfunction following restorative proctectomy, commonly referred to as Low Anterior Resection Syndrome (LARS), is a common long term sequela of rectal cancer treatment. While many of the established risk factors for LARS are non-modifiable, others may be well within the surgeon’s [...] Read more.
Postoperative bowel dysfunction following restorative proctectomy, commonly referred to as Low Anterior Resection Syndrome (LARS), is a common long term sequela of rectal cancer treatment. While many of the established risk factors for LARS are non-modifiable, others may be well within the surgeon’s control. Several pre-, intra-, and postoperative decisions may have a significant impact on postoperative bowel function. Some of these factors include the extent of surgical resection, surgical approach, choice of anastomotic reconstruction, and use of fecal diversion. This review article summarizes the available evidence regarding how surgical decision-making can affect postoperative bowel function. Full article
(This article belongs to the Special Issue Patient-Centered Outcomes of Colorectal Cancer Surgery)
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