Head and Neck Cancers—Novel Approaches and Future Outlook
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Biomarkers".
Deadline for manuscript submissions: 31 October 2024 | Viewed by 10574
Special Issue Editor
Interests: tumor models; immunotherapy; personalized treatment; T cells; tumor microenvironment
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Head and neck squamous cell carcinomas (HNSCCs) are highly heterogeneous. This heterogeneity complicates treatment, and hence, significant advances and improvements in patients’ outcome are needed.
Today, HNSCCs can be stratified according to the human papillomavirus (HPV) infection status, either being negative or positive. Despite the better overall prognosis in case of the latter, many patients present with loco-regionally advanced disease at diagnosis, and this patient cohort has a poor prognosis. The implementation of PD1 targeting antibodies has only moderately improved outcomes. There is increasing evidence of better efficacy in neoadjuvant settings, yet no consensus has been reached to date. This is at least partially attributable to the lack of reliable predictive biomarkers to identify patients with a high likelihood of benefitting from novel treatments. Hence, the implementation of more effective therapies constitutes an unmet need for improving outcomes.
For this Special Issue, we welcome original and review papers that deal with the challenges and recent advances in HNSCC treatment. We especially look for papers that provide insight into new and original research methodologies, better-quality early detection strategies, original treatment approaches, and organization of patients’ care.
Dr. Claudia Maletzki
Guest Editor
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Keywords
- tumor microenvironment
- biomarker
- patient-derived tumor models
- novel treatment approaches
- combination strategies
- prognostic marker
- liquid biopsy
- neoadjuvant treatment
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