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Cancers
Special Issues
Surgical Treatments and Modern Techniques in Colorectal Cancer
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Surgical Treatments and Modern Techniques in Colorectal Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2537

Special Issue Editors

Dr. Gianluca Rizzo

E-Mail Website
Guest Editor
Digestive and Colorectal Unit, Fatebenefratelli Isola Tiberina Gemelli Isola Hospital, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
Interests: rectal cancer; colon cancer; complete mesocolic excision; mini-invasive surgery; organ sparing
Dr. Vincenzo Tondolo

E-Mail Website
Guest Editor
Digestive and Colorectal Unit, Fatebenefratelli Isola Tiberina Gemelli Isola Hospital, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
Interests: rectal cancer; colon cancer; complete mesocolic excision; mini-invasive surgery; liver metastasis

Special Issue Information

Dear Colleagues,

Colorectal cancer represents the third most frequent cancer in Western countries. During the last thirty years the management of this kind of tumor has undergone profound changes thanks to the introduction of increasingly modern and precise technologies. Moreover, new standards of oncological radicality have been introduced to improve the oncological outcome of colorectal cancer. At the same time, especially in rectal cancer, the progressive improvement of integrated treatments has allowed the introduction of organ-sparing approaches with promising results. Nonetheless, there are still several topics of debate for which various studies are ongoing and on which it is not yet possible to establish a clear recommendation.

The focus of this Special Issue is systematically analyzing the most important aspects of surgical and multidisciplinary management of colorectal cancer, evaluating the impact of new surgical techniques and modern standards of treatment on the oncological outcome and quality of life of patients.

Dr. Gianluca Rizzo
Dr. Vincenzo Tondolo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • colorectal cancer
  • complete mesocolic excision
  • mini-invasive surgery
  • robotic surgery
  • organ sparing
  • liver metastasis
  • early rectal cancer

Published Papers (2 papers)

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Research

19 pages, 2616 KiB  
Article
NIR ICG-Enhanced Fluorescence: A Quantitative Evaluation of Bowel Microperfusion and Its Relation to Central Perfusion in Colorectal Surgery
by Norma Depalma, Stefano D’Ugo, Farshad Manoochehri, Annarita Libia, William Sergi, Tiziana R. L. Marchese, Stefania Forciniti, Loretta L. del Mercato, Prisco Piscitelli, Stefano Garritano, Fabio Castellana, Roberta Zupo and Marcello Giuseppe Spampinato
Cancers 2023, 15(23), 5528; https://doi.org/10.3390/cancers15235528 - 22 Nov 2023
Viewed by 854
Abstract
Background: To date, no standardized protocols nor a quantitative assessment of the near-infrared fluorescence angiography with indocyanine green (NIR-ICG) are available. The aim of this study was to evaluate the timing of fluorescence as a reproducible parameter and its efficacy in predicting anastomotic [...] Read more.
Background: To date, no standardized protocols nor a quantitative assessment of the near-infrared fluorescence angiography with indocyanine green (NIR-ICG) are available. The aim of this study was to evaluate the timing of fluorescence as a reproducible parameter and its efficacy in predicting anastomotic leakage (AL) in colorectal surgery. Methods: A consecutive cohort of 108 patients undergoing minimally invasive elective procedures for colorectal cancer was prospectively enrolled. The difference between macro and microperfusion (ΔT) was obtained by calculating the timing of fluorescence at the level of iliac artery division and colonic wall, respectively. Results: Subjects with a ΔT ≥ 15.5± 0.5 s had a higher tendency to develop an AL (p < 0.01). The ΔT/heart rate interaction was found to predict AL with an odds ratio of 1.02 (p < 0.01); a cut-off threshold of 832 was identified (sensitivity 0.86, specificity 0.77). Perfusion parameters were also associated with a faster bowel motility resumption and a reduced length of hospital stay. Conclusions: The analysis of the timing of fluorescence provides a quantitative, easy evaluation of tissue perfusion. A ΔT/HR interaction ≥832 may be used as a real-time parameter to guide surgical decision making in colorectal surgery. Full article
(This article belongs to the Special Issue Surgical Treatments and Modern Techniques in Colorectal Cancer)
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12 pages, 1573 KiB  
Article
Colorectal Pulmonary Metastases: Pulmonary Metastasectomy or Stereotactic Radiotherapy?
by Martijn van Dorp, Constantia Trimbos, Wilhelmina H. Schreurs, Chris Dickhoff, David J. Heineman, Bart Torensma, Geert Kazemier, Frank J. C. van den Broek, Ben J. Slotman and Max Dahele
Cancers 2023, 15(21), 5186; https://doi.org/10.3390/cancers15215186 - 28 Oct 2023
Viewed by 1345
Abstract
Background: Pulmonary metastasectomy and stereotactic ablative radiotherapy (SABR) are both guideline-recommended treatments for selected patients with oligometastatic colorectal pulmonary metastases. However, there is limited evidence comparing these local treatment modalities in similar patient groups. Methods: We retrospectively reviewed records of consecutive patients treated [...] Read more.
Background: Pulmonary metastasectomy and stereotactic ablative radiotherapy (SABR) are both guideline-recommended treatments for selected patients with oligometastatic colorectal pulmonary metastases. However, there is limited evidence comparing these local treatment modalities in similar patient groups. Methods: We retrospectively reviewed records of consecutive patients treated for colorectal pulmonary metastases with surgical metastasectomy or SABR from 2012 to 2019 at two Dutch referral hospitals that had different approaches toward the local treatment of colorectal pulmonary metastases, one preferring surgery, the other preferring SABR. Two comparable patient groups were identified based on tumor and treatment characteristics. Results: The metastasectomy group comprised 40 patients treated for 69 metastases, and the SABR group had 60 patients who were treated for 90 metastases. Median follow-up was 38 months (IQR: 26–67) in the surgery group and 46 months (IQR: 30–79) in the SABR group. Median OS was 58 months (CI: 20–94) in the metastasectomy group and 70 months (CI: 29–111) in the SABR group (p = 0.23). Five-year local recurrence-free survival (LRFS) was 44% after metastasectomy and 30% after SABR (p = 0.16). Median progression-free survival (PFS) was 15 months (CI: 3–26) in the metastasectomy group and 10 months (CI: 6–13) in the SABR group (p = 0.049). Local recurrence rate was 12.5/7.2% of patients/metastases respectively after metastasectomy and 38.3/31.1% after SABR (p < 0.001). Lower BED Gy10 was correlated with an increased likelihood of recurrence (p = 0.025). Clavien Dindo grade III-V complication rates were 2.5% after metastasectomy and 0% after SABR (p = 0.22). Conclusion: In this retrospective cohort study, pulmonary metastasectomy and SABR had comparable overall survival, local recurrence-free survival, and complication rates, despite patients in the SABR group having a significantly lower progression-free survival and local control rate. These data would support a randomized controlled trial comparing surgery and SABR in operable patients with radically resectable colorectal pulmonary metastases. Full article
(This article belongs to the Special Issue Surgical Treatments and Modern Techniques in Colorectal Cancer)
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