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Cancers
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Impact of Surgery on Brain Cancer and Other Central Nervous...
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Impact of Surgery on Brain Cancer and Other Central Nervous System Tumors

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 15 July 2025 | Viewed by 3168

Special Issue Editors

Dr. Paolo Tini

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Guest Editor
1. Radiation Oncology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Viale Bracci, 16, 53100 Siena, Italy
2. Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA, USA
Interests: brain tumors; stereotactic radiosurgery; radiobiology; combined treatments; gliomas; brain metastases; molecular markers
Special Issues, Collections and Topics in MDPI journals
Dr. Francesco Marampon

E-Mail Website
Guest Editor
Department of Radiotherapy, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy
Interests: radiotherapy; radio-resistance; rhabdomyosarcoma; adult cancers; epigenetic drugs; targeted therapy; ERK functions; MYC
Special Issues, Collections and Topics in MDPI journals
Dr. Giuseppe Minniti

E-Mail Website
Guest Editor
1. Department of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University of Rome, Policlinico Umberto I, Rome, Italy
2. IRCCS Neuromed, Pozzilli, IS, Italy
Interests: neuro-oncology; radiotherapy in CNS cancers; radiosurgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In CNS oncological disease, surgery plays a key role in the treatment. Modern neurosurgery has allowed a broadening of resectability criteria by improving both extension and postoperative side effects. However, radical surgery is not always possible given the treatment site. This Special Issue would like to take stock of the impact of surgical treatment in clinical terms.

We hope to stimulate scientific attention on a delicate and highly impacting aspect in determining the clinical outcome of patients with brain and CNS neoplasms, such as surgical extension, which is a point that has still not been clarified in various oncological pathologies of the central nervous system. We believe it is necessary to develop a Special Issue to collect works focused on the impact and role of surgery in different oncological diseases in CNS. We look forward to your contributions.

Dr. Paolo Tini
Dr. Francesco Marampon
Dr. Giuseppe Minniti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • glioblastoma
  • low-grade gliomas
  • ependymomas
  • PNET
  • meningiomas
  • medulloblastomas
  • other brain tumors

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Published Papers (2 papers)

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Review

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19 pages, 3826 KiB  
Review
Interdisciplinary Therapeutic Approaches to Atypical and Malignant Meningiomas
by Leonidas Trakolis and Athanasios K. Petridis
Cancers 2023, 15(17), 4251; https://doi.org/10.3390/cancers15174251 - 25 Aug 2023
Cited by 2 | Viewed by 1966
Abstract
Meningiomas have the highest incidence among brain tumors. In contrast to benign tumors that constitute the majority of this tumor entity, the treatment of aggressive meningiomas (WHO Grade 2 and 3) is more challenging, requiring gross total removal of the tumor and the [...] Read more.
Meningiomas have the highest incidence among brain tumors. In contrast to benign tumors that constitute the majority of this tumor entity, the treatment of aggressive meningiomas (WHO Grade 2 and 3) is more challenging, requiring gross total removal of the tumor and the affected dura and adjuvant radiotherapy. Sometimes the location and/or the configuration of the tumor do not favor radical surgical resection without endangering the patient’s clinical condition after surgery and pharmacological therapy has, until now, not been proven to be a reliable alternative. Discussion: In this narrative review, we discuss the current literature with respect to the management of meningiomas, discussing the importance of the grade of resection in the overall prognosis of the patient and in the planning of adjuvant therapy. Conclusions: According to the location and size of the tumor, radical resection should be taken into consideration. In patients with aggressive meningiomas, adjuvant radiotherapy should be performed after surgery. In cases of skull base meningiomas, a maximal, though safe, resection should take place before adjuvant therapy. An interdisciplinary approach is beneficial for patients with primary or recurrent meningioma. Full article
(This article belongs to the Special Issue Impact of Surgery on Brain Cancer and Other Central Nervous System Tumors)
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Other

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11 pages, 823 KiB  
Perspective
Challenges and Opportunities in Accessing Surgery for Glioblastoma in Low–Middle Income Countries: A Narrative Review
by Paolo Tini, Giovanni Rubino, Pierpaolo Pastina, Salvatore Chibbaro, Alfonso Cerase, Francesco Marampon, Sergio Paolini, Vincenzo Esposito and Giuseppe Minniti
Cancers 2024, 16(16), 2870; https://doi.org/10.3390/cancers16162870 - 17 Aug 2024
Viewed by 634
Abstract
Glioblastoma: a highly aggressive brain tumor, presents substantial challenges in treatment and management, with surgical intervention playing a pivotal role in improving patient outcomes. Disparities in access to brain tumor surgery arise from a multitude of factors, including socioeconomic status, geographical location, and [...] Read more.
Glioblastoma: a highly aggressive brain tumor, presents substantial challenges in treatment and management, with surgical intervention playing a pivotal role in improving patient outcomes. Disparities in access to brain tumor surgery arise from a multitude of factors, including socioeconomic status, geographical location, and healthcare resource allocation. Low- and middle-income countries (LMICs) often face significant barriers to accessing surgical services, such as shortages of specialized neurosurgical expertise, limited healthcare infrastructure, and financial constraints. Consequently, glioblastoma patients in LMICs experience delays in diagnosis, suboptimal treatment, and poorer clinical outcomes compared to patients in high-income countries (HICs). The clinical impact of these disparities is profound. Patients in LMICs are more likely to be diagnosed at advanced disease stages, receive less effective treatment, and have lower survival rates than their counterparts in HICs. Additionally, disparities in access to surgical care exacerbate economic and societal burdens, emphasizing the urgent need for targeted interventions and health policy reforms to address healthcare inequities. This review highlights the importance of addressing global disparities in access to brain tumor surgery for glioblastoma through collaborative efforts, policy advocacy, and resource allocation, aiming to improve outcomes and promote equity in surgical care delivery for all glioblastoma patients worldwide. Full article
(This article belongs to the Special Issue Impact of Surgery on Brain Cancer and Other Central Nervous System Tumors)
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