Biomarkers and Targeted Therapy in Malignant Pleural Mesothelioma
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Biomarkers".
Deadline for manuscript submissions: 15 March 2025 | Viewed by 48
Special Issue Editor
Interests: malignant mesothelioma; target therapy; lung cancer; immunotherapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
As the Guest Editors of the Special Issue below, I would like to invite you or one of your colleagues to contribute an original research or review article that addresses the topic of “Biomarkers and Targeted Therapy in Malignant Pleural Mesothelioma”.
Malignant pleural mesothelioma is a rare tumor associated with asbestos exposure. Treatment options are limited to date, with a median survival of about 18 months. Treatment with immunotherapy improves survival, but not all patients respond to immunotherapy, and those who do will relapse. Up until now, immunotherapy-predictive biomarkers used in other tumors have not demonstrated a clear predictive role in MPM (TMB, PD-L1). However, histology, in first-line treatment, does seem to have a predictive role in response to treatment.
Moreover, numerous genomic and transcriptomic studies have identified recurrent molecular alterations in MPM (BAP1, CDKN2a, MTAP). Despite this, there are no approved targeted therapies for the most frequent alterations. On the other hand, chromosomal alterations such as chromoptisis seem to play a predictive role in response to immunotherapy.
The aim of this review is to evaluate the possible predictive factors of responses to approved treatments (histology, TMB, PD-L1) and the genomic and transcriptomic alterations that occur in patients with MPM (BAP1, CDKN2a, MTAP...), placing them in the context of possible treatments.
Based on your expertise in this field, we would like to invite you to contribute with a review for a full research paper or an original manuscript for peer review and possible publication in this Special Issue.
I hope that this invitation receives your favorable consideration. We look forward to our future collaboration.
Best wishes,
Dr. Susana Cedrés
Guest Editor
Manuscript Submission Information
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Keywords
- malignant mesothelioma
- target therapy
- biomarkers
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