Hereditary and Familial Colorectal Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 745
Special Issue Editors
Interests: gastrointestinal cancer; gastric cancer; colorectal cancer; lynch syndrome; pancreatic cancer
Special Issue Information
Dear Colleagues,
Hereditary and familial colorectal cancers represent nearly a quarter of all colorectal cancers diagnosed. This is caused by identifiable pathogenic germline variants in colorectal cancer risk genes, leading to known hereditary colorectal cancer risk syndromes such as Lynch syndrome or familial adenomatous polyposis (FAP), or may be also related to other familial factors that are less well defined. Identification of and germline genetic testing for these high-risk individuals and families is of paramount importance in terms of allowing for syndrome identification and risk stratification. Enhanced colorectal cancer and often extra-colonic cancer screening is important in terms of reduce morbidity and mortality in inidividuals with hereditary and familial colorectal cancer risk. Finally, cancer prevention through lifestyle modifications and chemoprevention may have a substantial impact on future cancer risk. This Special Issue of Cancers will be focused on hereditary and familial colorectal cancer, with a focus on identification of high-risk individuals and families, genetic testing, risk assessment, screening implementation and outcomes, and cancer prevention.
Dr. Bryson W. Katona
Dr. Peter P. Stanich
Guest Editors
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Keywords
- hereditary colorectal cancer
- familial colorectal cancer
- genetic predisposition
- polyposis
- Lynch syndrome
- familial adenomatous polyposis (FAP)
- MUTYH-associated polyposis (MAP)
- genetic testing
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