Emerging Concepts in Mesothelioma

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 743

Special Issue Editors


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Guest Editor
School of Medicine, University of Cyprus, Aglantzia, Nicosia 2109, Cyprus
Interests: biology of lung cancer and mesothelioma; interstitial lung diseases

E-Mail Website
Guest Editor
Department of Pulmonary Medicine, Nicosia General Hospital, State Health Services Organization, Aglantzia, Nicosia 2100, Cyprus
Interests: biology of lung cancer and mesothelioma; Interstitial lung diseases

Special Issue Information

Dear Colleagues,

Despite extensive research efforts, mesothelioma is still tremendously difficult to treat and mesothelioma incidence rates have not declined significantly despite asbestos bans in more developed countries, while a new incipient and protracted epidemic caused by alternate needle-shaped materials is likely. In these dreadful times, the molecular landscape, the potential treatment strategies, and hopes for the future for patients with mesothelioma are vague. We are pleased to invite you to contribute a piece of certainty to the volatile scenery of mesothelioma diagnosis and treatment in a Special Issued entitled “Emerging Concepts in Mesothelioma”, based on your excellent contributions and involvement in the field.

This Special Issue aims to summarize past understanding and recent progress in mesothelioma research and treatment, and to provide a platform for the guidance of future developments, i.e., molecular profiling, drug screening, patient subgroups and geno/phenotypes, trial design, personalized medicine, etc.

Original research, reviews, and opinion pieces are sought and the involvement of your collaborators and students is welcome. We propose a topic based on your achievements, but this is subject to change. We look forward to receiving your contributions.

Dr. Georgios T. Stathopoulos
Dr. Tonia Adamides
Guest Editors

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Keywords

  • mesothelioma
  • asbestos
  • pleura
  • tumor suppressor
  • cell lines
  • patient-derived xenograft
  • surgery
  • chemotherapy
  • folate antagonist
  • immunotherapy

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Published Papers (1 paper)

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Research

10 pages, 1144 KB  
Article
Malignant Local Seeding in Procedure Tracts of Pleural Mesothelioma: Incidence and Novel Risk Factors in 308 Patients
by Moshe Lapidot, Emanuele Mazzola and Raphael Bueno
Cancers 2025, 17(17), 2786; https://doi.org/10.3390/cancers17172786 - 26 Aug 2025
Viewed by 434
Abstract
Background/Objectives: Unlike other thoracic malignancies, seeding malignant cells along surgical tracts is a known complication of invasive diagnostic or therapeutic procedures for pleural mesothelioma (PM). We report the tract dissemination rate and risk factors in 308 consecutive patients treated over 9 years [...] Read more.
Background/Objectives: Unlike other thoracic malignancies, seeding malignant cells along surgical tracts is a known complication of invasive diagnostic or therapeutic procedures for pleural mesothelioma (PM). We report the tract dissemination rate and risk factors in 308 consecutive patients treated over 9 years in a single institution who underwent pleurectomy decortication (PD). Methods: Clinical and outcome data were reviewed. Fisher’s exact test, Kaplan–Meier estimators, and log-rank tests were used to identify significant risk factors for surgical tract dissemination and to compare overall survival. Results: There were 233 males (75.6%), 187 right-sided operations (61%), 190 (61.7%) epithelioid histology cases, and the median age was 69 (29–84). During the study, malignant cell dissemination in resected surgical tracts was diagnosed in 69 (22.4%) patients. The dissemination rates in epithelioid, biphasic, and sarcomatoid tumors were 24.7%, 20.4%, and 0%, respectively. Disseminated malignant surgical tract was associated with advanced nodal status (p = 0.001), advanced staging by the American Joint Committee on Cancer (AJCC 8th edition, p = 0.03), female sex (0.02), side of surgery (p = 0.03), and the number of video-assisted thoracoscopic surgery (VATS) ports (p = 0.003). In epithelioid mesothelioma, the median survival from diagnosis was 19.7 months in patients with tract seeding versus 36.3 months in patients without seeding (hazard ratio, 1.9; p = 0.001). Conclusions: Procedure tract dissemination occurs in almost every fourth patient with pleural mesothelioma and is associated with shorter overall survival in the epithelioid subtype. Full article
(This article belongs to the Special Issue Emerging Concepts in Mesothelioma)
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