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Cancers
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New Diagnostic and Therapeutic Perspectives of Gynecological Carcinomas
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New Diagnostic and Therapeutic Perspectives of Gynecological Carcinomas

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 2473

Special Issue Editor

Dr. Carlo Ronsini

E-Mail Website
Guest Editor
Department of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 81100 Caserta, CE, Italy
Interests: gynecologic oncology; surgical gynecology; biomarkers; endometrial carcinoma; ovarian carcinoma; cervical carcinoma
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue of Cancer aims to explore diagnostic and therapeutic innovations in gynecologic carcinomas. Despite advances in understanding their molecular basis, the treatment and management of these malignancies remain a significant challenge. The ultimate goal is to explore new strategies to improve early diagnosis, identify predictive biomarkers, and develop personalized approaches, focusing on immunotherapy, targeted therapies, and precision medicine.

In addition, innovative aspects in surgery, radiation therapy, and integrative therapies will be addressed. We welcome original contributions and reviews highlighting the latest findings, with the intension of providing a comprehensive overview of future opportunities to improve patients’ survival and quality of life.

Researchers are invited to contribute to this Special Issue with novel original trials, reviews, and meta-analyses to raise awareness of gynecological cancer. We invite oncologists, gynecologists, biologists, nurses, psychologists, and researchers in related fields to contribute their robust scientific manuscripts. 

I look forward to receiving your contributions.

Dr. Carlo Ronsini
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gynecologic oncology
  • surgical gynecology
  • biomarkers
  • endometrial carcinoma
  • ovarian carcinoma
  • cervical carcinoma

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Published Papers (2 papers)

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14 pages, 1445 KB  
Systematic Review
Comparative Efficacy of Treatment Methods and Risk Factors for Treatment Failure in High-Grade Vaginal Intraepithelial Neoplasia: A Systematic Review and Meta-Analysis
by Franciszek Ługowski, Magdalena Papież and Barbara Suchońska
Cancers 2026, 18(8), 1302; https://doi.org/10.3390/cancers18081302 - 20 Apr 2026
Abstract
Background: High-grade vaginal intraepithelial neoplasia (VaIN 2+) is a rare condition with limited evidence to guide optimal management. This study aimed to evaluate the efficacy of various treatment strategies and identify clinical risk factors associated with treatment failure. Methods: A systematic literature search [...] Read more.
Background: High-grade vaginal intraepithelial neoplasia (VaIN 2+) is a rare condition with limited evidence to guide optimal management. This study aimed to evaluate the efficacy of various treatment strategies and identify clinical risk factors associated with treatment failure. Methods: A systematic literature search in PubMed, Scopus, Web of Science, and Cochrane databases was performed following PRISMA guidelines. The meta-analysis included 15 retrospective studies including patients treated for VaIN 2+. Pooled risk ratios (RRs) with 95% confidence intervals (CIs) were calculated for treatment modalities (laser ablation, surgical excision, topical therapy) and clinical risk factors (prior hysterectomy, multifocality, immunosuppression, HPV16 infection and history of cervical intraepithelial neoplasia (CIN)). Results: Immunosuppression was significantly associated with a higher risk of treatment failure (RR = 2.01; 95% CI 1.12–3.60; p = 0.030). Topical therapies were found to have a significantly higher risk of treatment failure compared to laser ablation (RR = 1.92; 95% CI 1.34–2.92; p = 0.009). No statistically significant difference in recurrence risk was found between laser ablation and surgical excision, and between surgical excision and topical therapy. Factors such as prior hysterectomy, multifocality, and history of CIN did not show a statistically significant association with recurrence in the pooled models. Conclusions: Immunosuppression is a critical risk factor for VaIN 2+ recurrence, highlighting the need for individualized management and closer surveillance in this population. Surgical and ablative methods appear superior to topical agents in controlling high-grade disease. Given the retrospective nature of current data, standardized prospective studies are required to refine treatment algorithms. Full article
(This article belongs to the Special Issue New Diagnostic and Therapeutic Perspectives of Gynecological Carcinomas)
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14 pages, 1482 KB  
Systematic Review
Safety and Efficacy Outcomes of Robotic, Laparoscopic, and Laparotomic Surgery in Severe Obese Endometrial Cancer Patients: A Network Meta-Analysis
by Carlo Ronsini, Mario Fordellone, Eleonora Braca, Mariano Catello Di Donna, Maria Cristina Solazzo, Giuseppe Cucinella, Cono Scaffa, Pasquale De Franciscis and Vito Chiantera
Cancers 2025, 17(12), 2018; https://doi.org/10.3390/cancers17122018 - 17 Jun 2025
Cited by 9 | Viewed by 2055
Abstract
Background: The surgical management of endometrial cancer in severely obese patients (BMI ≥ 40) presents unique challenges. This study evaluates the outcomes of various surgical approaches in terms of safety and efficacy in lymph node retrieval. Methods: A systematic review and network meta-analysis [...] Read more.
Background: The surgical management of endometrial cancer in severely obese patients (BMI ≥ 40) presents unique challenges. This study evaluates the outcomes of various surgical approaches in terms of safety and efficacy in lymph node retrieval. Methods: A systematic review and network meta-analysis focused on intra-operative complications, post-operative complications, severe complications, and complete surgical staging rates. The analysis included 1163 patients, following a pre-specified methodology based on the PRISMA-NMA guidelines. The study was registered on PROSPERO with protocol number CRD 395959. Results: Intra-operative complications: No significant difference was found between minimally invasive surgery (MIS, 233 patients) and laparotomy (LPT) (OR 0.68 [95% CI 0.21–2.26], p = 0.18). However, robotic surgery showed a significantly lower risk (OR 0.28 [0.10–0.74]). Post-operative complications: The MIS group (457 patients) had a lower risk compared to LPT (OR 0.41 [0.26–0.64]). Network analysis: Robotic surgery had a 70.7% probability of reducing intra-operative complications compared to laparoscopy (LPS) and a 99.2% probability compared to LPT. Laparoscopy was the safest option for post-operative complications, with a 74.3% probability. Robotic surgery had an 82.4% probability of achieving complete surgical staging compared to LPT. Conclusions: Robotic surgery shows superior outcomes for complete lymph nodal staging in obese endometrial cancer patients, while LPS is favorable for post-operative complications. Further studies are needed to optimize strategies. Full article
(This article belongs to the Special Issue New Diagnostic and Therapeutic Perspectives of Gynecological Carcinomas)
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