Soft Tissue Sarcomas—New Diagnostic and Therapeutic Perspectives Through Clinical Genomic Profiling
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 1360
Special Issue Editors
2. Medical Faculty, University of Tübingen, 72076 Tübingen, Germany
Interests: rhabdomyosarcoma
Special Issues, Collections and Topics in MDPI journals
2. Medical Faculty, University of Tübingen, 72076 Tübingen, Germany
Interests: rhabdomyosarcoma
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Soft tissue sarcomas (STS) are a group of more than 70 different tumors that occur in children and adults. The diagnosis of STS is considered the most challenging field of diagnostic pathology. The introduction of molecular genetics to microscopic morphology and immunohistochemistry has been a major advance that has refined the diagnosis and classification of STS. However, therapeutic options have not changed substantially over the last few decades, and precision-based therapeutics have been introduced in only a few entities.
Transcriptional signature derived from expression of 67 genes, CINSARC outperformed the FNCLCC grading system but showed weak prognostic value in some groups of patients and is still not widely used as a basis of clinical decision. Comprehensive molecular profiling will hopefully open a new era in the diagnosis, classification, and therapy of STS.
It is also evident that a more accurate prediction of the risk of recurrence at the end of STS is urgently needed. Circulating tumor DNA (ctDNA) testing has begun to be used as a prognostic marker for therapy stratification and more precise patient enrollment in randomized trials in many malignancies and will hopefully soon be used in STS.
There is still a long way to go in order to characterize all STS molecularly and introduce new biomarkers into clinical routine. Many researchers all over the world are working on these topics, and we offer the new Special Issue as a way to publish and cumulate different results, facilitating exchange and comparisons.
Prof. Dr. Ewa Koscielniak
Prof. Dr. Monika Sparber-Sauer
Guest Editors
Manuscript Submission Information
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Keywords
- soft tissue sarcoma
- molecular profiling
- cancer genomics
- personalized medicine
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