The Role of RNAs in Cancers
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: 30 September 2024 | Viewed by 249
Special Issue Editor
Special Issue Information
Dear Colleagues,
Significant advances in RNA-based next-generation sequencing, single-cell transcriptomics, and third-generation long-read sequencing technologies have provided unprecedented depth and scope for understanding the role of RNA processing in diagnostics and leveraging potential new modes of therapies for undruggable targets in cancers. RNA-seq methods have led to the discovery of novel biomarkers in identifying differentially expressed miRNA, lncRNA, circRNA and fusion transcripts, enabling highly granular molecular characterizations of cancer subtypes that promise to actualize personalized medicine. Advances in separation science and nanotechnology platforms have helped to overcome some drawbacks of introducing RNA molecules into the body, such as the rapid degradation in human tissues; eliciting immunogenicity and Impermeability across membranes, promoting clinical trials for RNA-based therapeutics. A range of therapeutic options are being developed including: antisense oligonucleotide (ASO), small interfering RNA (siRNA), microRNA, aptamers, mRNA replacement and mRNA vaccines. This Special Issue reports on recent advances in RNA biology that will expand diagnostic and therapeutic capabilities for treating cancers.
Dr. Sanjive Qazi
Guest Editor
Manuscript Submission Information
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Keywords
- RNA biology
- next generation sequencing
- RNA based therapeutics personalized medicine
- nanotechnology
- cancers
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