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Clinical Research in Ocular Oncology

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 1281

Special Issue Editors


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Guest Editor
1. Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, TN, USA
2. Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA
Interests: ocular oncology

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Guest Editor
Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH 44106, USA
Interests: ocular oncology; uveal melanoma; retinoblastoma
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Ophthalmology, Copenhagen University Hospital—Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
Interests: uveal melanoma; ophthalmology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue will cover all aspects of clinical research in ocular oncology. Research related to all types of ophthalmic cancers is welcome: intraocular, periocular and orbital tumors, including both benign and malignant neoplasms. Authors are encouraged to consider submissions related to diagnosis, treatment, medical systems, and patient-reported outcomes/quality of life. We welcome original research articles, reviews, communications, and systematic reviews covering various aspects of clinical research in ophthalmic cancers.

Dr. Anthony Daniels
Dr. Arun D. Singh
Prof. Dr. Jens Folke Kiilgaard
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ocular oncology
  • eye cancer
  • tumors
  • melanoma
  • retinoblastoma
  • hemangioma
  • hemangioblastoma
  • lymphoma

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Published Papers (1 paper)

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Review

17 pages, 1541 KB  
Review
Conjunctival Squamous Cell Carcinoma: A Clinical Review of Diagnostic Features, Genetics, Current Management and an Update on Targeted and Immunotherapies
by Murad Mir, Hardeep Singh Mudhar, Mandeep S. Sagoo, Stephen Gichuhi and Yamini Krishna
Cancers 2026, 18(6), 940; https://doi.org/10.3390/cancers18060940 - 13 Mar 2026
Viewed by 933
Abstract
Invasive conjunctival squamous cell carcinoma (CSCC) is an aggressive, ocular surface malignancy. The mean annual age-standardised incidence rate of 0.45 cases per million per year is increasing with an average annual percent rise of 4.5% and occurs mainly in over 65-year-olds in temperate [...] Read more.
Invasive conjunctival squamous cell carcinoma (CSCC) is an aggressive, ocular surface malignancy. The mean annual age-standardised incidence rate of 0.45 cases per million per year is increasing with an average annual percent rise of 4.5% and occurs mainly in over 65-year-olds in temperate climates but in a younger demographic in the tropics. Invasive CSCC can lead to vision loss either from the destructive effects of the tumour or side effects of therapy, facial disfigurement from radical surgery, and death from metastases. There is no standardised treatment and not all cases are referred to a specialist ocular oncology centre. Recent progress in cancer immunology and genetics has revolutionised the treatment of cutaneous and head and neck SCCs, which share some similarities to invasive CSCC. A better understanding of invasive CSCC and its preinvasive intraepithelial lesions is required to lead to the development of novel targeted and immunotherapies both for local tumour control, globe sparing alternatives and to prevent disseminated disease. This review aims to provide a comprehensive clinical overview of the current knowledge regarding CSSC, its epidemiology, pathogenesis, presentation, diagnosis, management, recent advances in targeted and immunotherapies for personalised treatment of this disease, and early diagnosis strategies to improve patient outcomes. Full article
(This article belongs to the Special Issue Clinical Research in Ocular Oncology)
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