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Cancers
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Biomarkers in Renal Cell Cancer
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Biomarkers in Renal Cell Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Biomarkers".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 1434

Special Issue Editor

Dr. Alejandro Sanchez

E-Mail Website
Guest Editor
Division of Urology, University of Utah School of Medicine, Salt Lake City, UT, USA
Interests: biomarkers; urologic surgical oncology; clear cell renal cell carcinoma; clinical trial development; translational research

Special Issue Information

Dear Colleagues,

We lack renal cell carcinoma (RCC) biomarkers to help inform critical clinical decisions. RCC biomarkers hold significant potential for early diagnosis, risk stratification, and treatment selection. This Special Issue on Biomarkers in RCC explores the current state of RCC biomarkers, discussing diagnostic, prognostic, and predictive biomarkers, while highlighting their advantages and limitations. We examine emerging technologies for biomarker discovery and challenges that must be addressed before clinical implementation. By delving into future perspectives, this Special Issue emphasizes the importance of a rigorous methodology, validation, and collaboration to advance the field of RCC biomarkers.

Dr. Alejandro Sanchez
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomarkers
  • renal cancer
  • clear cell renal cell carcinoma
  • non-clear cell renal cell carcinoma
  • systemic therapy
  • body composition
  • radiomics
  • blood biomarkers
  • tissue biomarkers
  • prognosis
  • risk prediction

Published Papers (2 papers)

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Research

9 pages, 440 KiB  
Article
The Prognostic Impact of the Surgical Margin in Renal Cell Carcinoma Treated with Partial Nephrectomy: A Multi-Center Study
by Karina Sif Søndergaard Mosholt, Mark Aagaard, Andreas Røder and Nessn Azawi
Cancers 2024, 16(8), 1449; https://doi.org/10.3390/cancers16081449 - 9 Apr 2024
Viewed by 547
Abstract
Background: Partial nephrectomy (PN) is the preferred treatment for small, localized kidney tumors. Incomplete resection resulting in positive surgical margins (PSM) can occur after PN. The impact of PSM on the risk of recurrence and survival outcomes is not fully understood. We aimed [...] Read more.
Background: Partial nephrectomy (PN) is the preferred treatment for small, localized kidney tumors. Incomplete resection resulting in positive surgical margins (PSM) can occur after PN. The impact of PSM on the risk of recurrence and survival outcomes is not fully understood. We aimed to explore the relationship between PSM, the risk of recurrence and impact on survival after PN in a large multicenter cohort from Denmark. Methods: This was a retrospective cohort study including patients who underwent PN for renal cell carcinoma (RCC) at three departments in Denmark between 2010 and 2016. Data including pathological features, surgical techniques, and patient follow-up was retrieved from electronic medical health records and national databases. We used a combination of descriptive statistics, comparative analysis (comparisons were carried out by Mann–Whitney Test, independent Student’s t-test, or Pearson’s chi-Square Test), univariate and multivariate logistic regression analyses, and survival analysis methods. Results: A total of 523 patients were included, of which 48 (9.1%) had a PSM. Recurrence was observed in 55 patients (10.5%). Median follow-up time was 75 months. We found a lower incidence of PSM with robot-assisted PN (p = 0.01) compared to open or laparoscopic PN. PSM was associated with a higher risk of recurrence compared to negative margins in univariate analysis, but not multivariate analysis. However, the study was underpowered to describe this association with other risk factors. Overall survival did not differ between patients with PSM and negative margins. Conclusions: Our study presents further evidence on the negative impact of PSM on recurrence after PN for RCC, highlighting the importance of achieving NSM, thus potentially improving clinical outcomes. A surgical approach was found to be the only predictive factor influencing the risk of PSMs, with a reduced risk observed with robot-assisted laparoscopy. Full article
(This article belongs to the Special Issue Biomarkers in Renal Cell Cancer)
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12 pages, 1490 KiB  
Article
RUVBL1 in Clear-Cell Renal Cell Carcinoma: Unraveling Prognostic Significance and Correlation with HIF1A
by Justyna Durślewicz, Aleksandra Maria Wybierała, Sara Szczepanek, Paulina Antosik, Damian Jaworski and Dariusz Grzanka
Cancers 2024, 16(7), 1273; https://doi.org/10.3390/cancers16071273 - 25 Mar 2024
Viewed by 668
Abstract
This study investigates the roles of RUVBL1 and HIF1A in ccRCC development and explores their clinical significance as prognostic biomarkers. mRNA and protein expressions were analyzed using TCGA data and an institutional tissue cohort, respectively. Correlations with clinicopathological parameters and patient outcomes were [...] Read more.
This study investigates the roles of RUVBL1 and HIF1A in ccRCC development and explores their clinical significance as prognostic biomarkers. mRNA and protein expressions were analyzed using TCGA data and an institutional tissue cohort, respectively. Correlations with clinicopathological parameters and patient outcomes were assessed. TCGA data revealed significantly elevated RUVBL1 mRNA expression in ccRCC tissues, associated with advanced histological grade, T stage, lymph node metastasis, and clinical stage. High RUVBL1 mRNA expression correlated with inferior overall survival and served as an adverse prognostic factor. Similarly, HIF1A mRNA expression was significantly higher in ccRCC tissues, correlating with worse overall survival and acting as an adverse prognostic factor for treatment outcomes. Simultaneous evaluation of RUVBL1 and HIF1A mRNA expression demonstrated enhanced prognostic capacity, surpassing the predictive power of individual markers. Immunohistochemical staining confirmed substantial upregulation of both RUVBL1 and HIF-1α proteins in ccRCC tissues. Furthermore, high expression of both RUVBL1 and HIF-1α proteins was significantly associated with shorter patient survival time. Our findings underscore the significance of RUVBL1 and HIF-1α as potential prognostic markers in ccRCC, paving the way for further research to translate these insights into clinically relevant applications. Full article
(This article belongs to the Special Issue Biomarkers in Renal Cell Cancer)
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