The Cancer Stem Cells and the Quiescence
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: 31 May 2025 | Viewed by 73
Special Issue Editor
Interests: stem cells (mammary stem cells, intestinal stem cells); cancer stem cells; breast cancer research; breast pathology; animal modeling; preclinical targeting; organoid systems; ovarian cancer research
Special Issue Information
Dear Colleagues,
Mounting evidence links cancer stem cells (CSCs) to tumor initiation, maintenance, resistance to therapy, recurrence and metastasis. CSCs are a small self-renewing population, associated with quiescent or dormant states rather than cycling, which makes them drug-resistant or refractory to treatment. Further, they initiate metastasis at distal organs, known to account for 90% of cancer-related mortality. To initiate metastasis at distant organs, CSCs can remain dormant for days to years. Upon receiving appropriate signaling cues, CSCs then give rise to metastasis. CSCs have been implicated as drug persisters, drug-tolerant populations, and dormant cells of tumors. There are also reports that propose that the dormancy and quiescence of CSCs exist as two different entities. Therefore, understanding the regulators of quiescence and/or dormancy of CSCs is an unmet goal to develop therapeutic strategies targeting therapy-resistant, metastatic, and recurrent cancers. Further experimental findings warrant better understanding of these two processes. To study CSC biology, it is essential to identify, isolate and propagate CSCs in in vitro and in vivo settings. The in vitro 3D culture of CSCs provides the opportunities to maintain a tumor-like state ex vivo, study tumor biology, and screen drugs and inhibitors. We would like to invite research and review papers on the broad field of cancer stem cells not limited to quiescence. This Special Issue of Cancers covers all aspects of CSCs, including the identification of novel markers of quiescent CSCs, animal models to understand CSC biology, metastasis, cell signaling, dormancy, metabolism, and preclinical and clinical studies of therapy developments. Expert opinions and systematic reviews are also welcome.
We look forward to receiving your contributions.
Dr. Bhopal Mohapatra
Guest Editor
Manuscript Submission Information
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Keywords
- cancer stem cells
- new markers
- organoid cultures
- cancer cell dormancy and quiescence
- metastasis
- animal models
- metabolism
- drug resistance
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