Treatment of Abdominal Tumors

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 195

Special Issue Editors


E-Mail Website
Guest Editor
Deaprtment of Surgery, University of Virginia, Charlottesville, VA, USA
Interests: hepatocellular carcinoma; colon cancer; tumor immune microenvironment; neutrophils; macrophage

E-Mail Website
Guest Editor
Deaprtment of Surgery, University of Virginia, Charlottesville, VA, USA
Interests: GI cancer; bioinformatics; liver pathology; tumor microenvironment

Special Issue Information

Dear Colleagues,

Abdominal tumors, including malignancies such as liver, pancreatic, colorectal, and gastric cancer represent, a significant clinical challenge due to their anatomical complexity and aggressive nature. These tumors often exhibit resistance to conventional treatments, necessitating the development of novel therapeutic strategies. Recent advancements in the treatment of abdominal tumors have focused on a multidisciplinary approach, integrating surgical innovations with targeted therapies and immunotherapy. The role of molecular and genetic profiling in personalizing treatment plans has also gained prominence, leading to improved outcomes for patients. However, despite these advances, challenges remain, particularly in overcoming treatment resistance and managing metastatic disease. This Special Issue aims to provide a comprehensive overview of current therapeutic strategies, highlight emerging research, and discuss future directions in the treatment of abdominal tumors. By bringing together insights from surgical oncology, molecular biology, and clinical research, this issue seeks to enhance our understanding of the mechanisms driving abdominal tumor progression and to explore innovative approaches for improving patient outcomes.

Dr. Hongji Zhang
Dr. Chengli Shen
Guest Editors

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Keywords

  • liver cancer
  • pancreatic cancer
  • colorectal cancer
  • gastric cancer
  • treatment resistance
  • surgical oncology
  • targeted therapy
  • molecular mechanisms

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Published Papers (1 paper)

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Research

14 pages, 2422 KiB  
Article
Modulation of PRC1 Promotes Anticancer Effects in Pancreatic Cancer
by Hajin Lee, An-Na Bae, Huiseong Yang, Jae-Ho Lee and Jong Ho Park
Cancers 2024, 16(19), 3310; https://doi.org/10.3390/cancers16193310 - 27 Sep 2024
Viewed by 148
Abstract
Background: Pancreatic cancer, while relatively uncommon, is extrapolated to become the second leading cause of cancer-related deaths worldwide. Despite identifying well-known markers like the KRAS gene, the exact regulation of pancreatic cancer progression remains elusive. Methods: Clinical value of PRC1 was [...] Read more.
Background: Pancreatic cancer, while relatively uncommon, is extrapolated to become the second leading cause of cancer-related deaths worldwide. Despite identifying well-known markers like the KRAS gene, the exact regulation of pancreatic cancer progression remains elusive. Methods: Clinical value of PRC1 was analyzed using bioinformatics database. The role of PRC1 was further evaluated through cell-based assays, including viability, wound healing, and sensitivity with the drug. Results: We demonstrate that PRC1 was significantly overexpressed in pancreatic cancer compared to pancreases without cancer, as revealed through human databases and cell lines analysis. Furthermore, high PRC1 expression had a negative correlation with CD4+ T cells, which are crucial for the immune response against cancers. Additionally, PRC1 showed a positive correlation with established pancreatic cancer markers. Silencing PRC1 expression using siRNA significantly inhibited cancer cell proliferation and viability and increased chemotherapeutic drug sensitivity. Conclusions: These findings suggest that targeting PRC1 in pancreatic cancer may enhance immune cell infiltration and inhibit cancer cell proliferation, offering a promising avenue for developing anticancer therapies. Full article
(This article belongs to the Special Issue Treatment of Abdominal Tumors)
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