Flow Cytometric Analysis in Cancer
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 14749
Special Issue Editors
Interests: flow cytometry; signal amplification; cell-specific molecular expression levels; bipolar disorder; major depressive disorder; PTSD; multiple sclerosis; acute myocardial infarction
Special Issues, Collections and Topics in MDPI journals
Interests: immune oncology; circulating tumour cells; immune function; antibody therapy; flow cytometry; clinical immunology; accreditation; lymphocytes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Flow cytometry is a powerful technology because it assesses cells or particles one at a time as they pass through the beams of lasers. Since clinical samples comprise cells of heterogeneous origins and capabilities, single cell analysis is advantageous. It allows for signals to be assigned to specific cellular subpopulations, thereby greatly enhancing the specificity and precision of the analysis.
The investigation of samples from patients with cancer has profited by flow cytometry in two specific ways. First, flow cytometry has been used as a tool for the analysis of the cancer cells. Most obviously, flow cytometry has been used to phenotype hematopoietic malignancies such as leukemias, lymphomas, and myelomas since they exist a priori as single cells, but more recently the analysis of exosomes and circulating tumor cells has demonstrated the value of the technology for solid tumors. Remote sensing of solid tumors by flow cytometric analysis of blood is a promising capability.
The second facet of flow cytometry in cancer involves the analysis of immunity including both the immune response to neoplastic cells and the effects of neoplastic cells on immune cells. Both adaptive immunity with the specific antigen receptors of T cells and B cells and innate immunity with pattern recognition receptors including monocytes and NK cells are pertinent to the response to neoplasia. Beyond signaling receptors for cancer, immunoregulatory mechanisms are crucial in responding to neoplastic cells. The importance of the PD1, TIGIT, and CD47 pathways have been demonstrated to be crucial in responding to cancer cells, and the capability of neoplasia to manipulate these checkpoints has been a major advance over the past few years.
In this Special Issue authors will describe how flow cytometric analysis has impacted studies of cancer.
Dr. David R. Kaplan
Prof. Dr. Ulrich Sack
Guest Editors
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