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Cancers
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Optimizing Surgical Procedures and Outcomes in Renal Cancer
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Optimizing Surgical Procedures and Outcomes in Renal Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: 20 December 2025 | Viewed by 3982

Special Issue Editors

Prof. Dr. Maciej Salagierski

E-Mail Website
Guest Editor
Urology Department, Faculty of Medicine and Health Science, University of Zielona Gora, Zielona Gora, Poland
Interests: renal cell carcinoma
Dr. Piotr Kania

E-Mail Website
Guest Editor
St. John Paul II Mazovian Provincial Hospital in Siedlce, Siedlce, Poland
Interests: laparoscopic urology; robotics & minimally invasive urology; urinary incontinence; urodynamics; urolithiasis; urogynecology & female urology; endourology; urologic oncology

Special Issue Information

Dear Colleagues,

We are delighted to announce the call for submissions to a Special Issue of Cancers focusing on the topic of "Optimizing Surgical Procedure and Outcomes in Renal Cancer". Renal cancer, particularly kidney cancer, is a significant health concern worldwide. The management of renal cancer requires careful consideration of surgical procedures to achieve optimal outcomes for patients.

This Special Issue aims to provide a comprehensive overview of the current knowledge and advancements in surgical procedures for renal cancer, with a particular focus on optimizing outcomes. We invite the submission of original research articles and reviews that cover various aspects of renal cancer surgery, including, but not limited to:

  1. Minimally invasive treatment options: the use of minimally invasive techniques, such as radiofrequency ablation (RFA), microwave ablation (MWA), and cryoablation (CA), in the management of kidney cancer.
  1. Surgical innovations: novel surgical approaches, including robotic-assisted surgery and laparoscopic procedures, for the treatment of renal cancer.
  1. Surgical planning and techniques: strategies for preoperative planning, intraoperative navigation, and surgical techniques to improve surgical precision and outcomes in renal cancer surgery.
  1. Patient selection and outcomes: identification of factors that influence patient selection for different surgical approaches and evaluation of short-term and long-term outcomes following renal cancer surgery.
  1. Multidisciplinary approaches: collaborative efforts involving urologists, radiologists, pathologists, and oncologists to optimize surgical decision making and postoperative management for renal cancer patients.

All submitted articles will undergo a rigorous peer review process to ensure the highest scientific quality and relevance to the field. We encourage contributions from researchers, clinicians, and experts in the field of renal cancer research and urology.

By consolidating the latest research findings and clinical experiences, we aim to enhance our understanding of renal cancer surgery and promote the development of strategies for optimizing surgical procedures and outcomes. We believe that your valuable contributions will significantly contribute to the success of this Special Issue.

Should you have any questions, require further information, or need any assistance, please do not hesitate to reach out to us. We are here to support and facilitate your participation in this Special Issue.

Thank you for your attention to this matter, and we look forward to receiving your valuable submissions.

Prof. Dr. Maciej Salagierski
Dr. Piotr Kania
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • renal cancer surgery
  • optimizing outcomes
  • minimally invasive techniques
  • surgical innovations
  • multidisciplinary approaches

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

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Research

12 pages, 531 KiB  
Article
A Single Port (SP) Approach Reduces the Risk of Postoperative Complications in Elderly Patients Undergoing Robotic-Assisted Partial Nephrectomy (RAPN)
by Valerio Santarelli, Fabio Maria Valenzi, Hakan Bahadır Haberal, Luca A. Morgantini, Juan R. Torres-Anguiano, Francesco Del Giudice, Benjamin I. Chung, Alessandro Sciarra and Simone Crivellaro
Cancers 2025, 17(8), 1324; https://doi.org/10.3390/cancers17081324 - 15 Apr 2025
Viewed by 49
Abstract
Introduction: In recent years, due to the increasing life expectancy and the growing popularity of nephron sparing strategies (NSS), more elderly and frail patients are undergoing Robotic-Assisted Partial Nephrectomy (RAPN) for the treatment of localized Renal Cell Carcinoma (RCC). A Single Port Approach [...] Read more.
Introduction: In recent years, due to the increasing life expectancy and the growing popularity of nephron sparing strategies (NSS), more elderly and frail patients are undergoing Robotic-Assisted Partial Nephrectomy (RAPN) for the treatment of localized Renal Cell Carcinoma (RCC). A Single Port Approach has demonstrated itself to reduce estimated blood loss (EBL), complication rates, and length of stay (LOS). In the present study, we aim to compare perioperative and postoperative outcomes of SP RAPN and Multi Port (MP) RAPN, with a focus on elderly patients. Materials and Methods: In the study, 293 cN0M0 RCC patients who underwent MP and SP RAPN performed at our institution from 2018 to 2024 were retrospectively reviewed. Clinical, demographic, patient, and tumor characteristics and perioperative variables were assessed across group A (<65 years old) and group B (≥65 years old) patients, as well as MP and SP cohorts. Subsequently, univariate and multivariate regression analyses were carried out, particularly for elderly patients, to evaluate the impact of selected preoperative and perioperative variables on the risk of 30-day postoperative complications. Results: Clinical and demographic characteristics were similar across the MP and SP cohorts of group A and group B. The SP cohort of both group A and group B demonstrated significantly higher rates of extraperitoneal access (75.9% vs. 26.6% for group A, p < 0.001 and 81.8% vs. 26.2% for group B, p < 0.001), shorter median operative times (186 [142.8–222] min vs. 190 [153–238] min for group A, p < 0.001 and 173.5 [143–228] min vs. 206 [178–237] min for group B, p < 0.001), and shorter median LOS (0 [0–1] days vs. 2 [1–3] days for group A, p < 0.001 and 0 [0,1] days vs. 2 [2–4] days for group B, p < 0.001). Moreover, for both groups, an SP approach required significantly longer median ischemia times (21 min [18–31] vs. 20 min [16–24] for group A, p = 0.02 and 24.5 min [20–28] vs. 19.5 min [16–26] for group B, p = 0.03). However, the SP cohort of group B, despite the lower rate of on-clamp procedures (63.4% vs. 90.5%, p = 0.03), demonstrated significantly lower median EBL (50 mL [31–142] vs. 100 mL [50–200], p = 0.03). At multivariate analysis, the SP approach was an independent predictor of lower 30-day postoperative complications (OR: 0.2, 95%CI 0.04–0.9, p = 0.04). Conclusions: In the present study, elderly patients undergoing SP RAPN did not demonstrate higher complication rates, EBL or hospitalization days compared to their younger counterparts. Moreover, an SP approach was found protective for 30-day postoperative complications. Our results suggest that SP RAPN is feasible and safe in older and frailer patients. Full article
(This article belongs to the Special Issue Optimizing Surgical Procedures and Outcomes in Renal Cancer)
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13 pages, 670 KiB  
Article
Complications of Tumor Nephrectomy with and Without Tumor Thrombus in the Vena Cava, Recorded with the Clavien–Dindo Classification: A Matched-Pair Analysis
by Ute Maria Frölich, Katharina Leucht, Marc-Oliver Grimm and Susan Foller
Cancers 2024, 16(20), 3523; https://doi.org/10.3390/cancers16203523 - 18 Oct 2024
Viewed by 869
Abstract
Background/Objectives: Radical nephrectomy (RN) with inferior vena cava thrombectomy (IVCT) is indicated for the curative management of renal cell carcinoma (RCC) with tumor thrombus (TT). In the literature, any direct comparison of complications between RNs with or without IVCT is lacking. The objective [...] Read more.
Background/Objectives: Radical nephrectomy (RN) with inferior vena cava thrombectomy (IVCT) is indicated for the curative management of renal cell carcinoma (RCC) with tumor thrombus (TT). In the literature, any direct comparison of complications between RNs with or without IVCT is lacking. The objective of this study was to analyze and compare complications after RNs with or without IVCT. Methods: A retrospective evaluation of the complications recorded in RCC patients who underwent RN with (TT group, n = 44) or without (non-TT group, n = 44) IVCT between 2009 and 2021 was conducted. The non-TT group was identified via propensity-score matched-pair analysis. Postoperative complications up until discharge or postoperative day 30, whichever came first, were classified using the Clavien–Dindo classification (CDC). Complications were categorized into cardiovascular, pulmonary, bleeding, gastrointestinal, neurological/psychiatric, wound, urinary tract, dysglycemia, and other groups. Statistical analyses using descriptive statistics included the chi2 and Mann–Whitney U tests. Results: All CDC-grade postoperative complications were more frequent in the TT than in the non-TT group regarding the number of patients affected (93% vs. 73%), as well as per patient (median: 3 vs. 1; p < 0.001). Complications in CDC grade ≥ 3 were rare and comparable between groups. Cardiovascular, gastrointestinal, neurological/psychiatric, and bleeding complications occurred significantly more often in the TT group. However, its small study population and retrospective character limit this study. Conclusions: Significantly more patients undergoing an RN-IVCT experience more frequent postoperative complications than patients with an RN but without IVCT. Surgeons performing the procedures should be experienced, and hospital staff should be trained in the early recognition and treatment of complications. Full article
(This article belongs to the Special Issue Optimizing Surgical Procedures and Outcomes in Renal Cancer)
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8 pages, 506 KiB  
Article
A National Study of the Rate of Benign Pathology After Partial Nephrectomy for T1 Renal Cell Carcinoma: Should We Be Satisfied?
by Luna van den Brink, Tess Debelle, Lieke Gietelink, Niels Graafland, Annebeth Ruiter, Axel Bex, Harrie P. Beerlage, R. Jeroen A. van Moorselaar, Brunolf Lagerveld and Patricia Zondervan
Cancers 2024, 16(20), 3518; https://doi.org/10.3390/cancers16203518 - 17 Oct 2024
Cited by 1 | Viewed by 944
Abstract
Objectives: To determine the rate of benign pathology in cT1 tumors following partial nephrectomy in the Netherlands, thereby evaluating the rate of overtreatment. Methods: Data were collected from a nationwide database containing histopathology of resected renal tissue from 2014 to 2022. Patients [...] Read more.
Objectives: To determine the rate of benign pathology in cT1 tumors following partial nephrectomy in the Netherlands, thereby evaluating the rate of overtreatment. Methods: Data were collected from a nationwide database containing histopathology of resected renal tissue from 2014 to 2022. Patients who underwent partial nephrectomy for suspected RCC staged T1a-b were extracted for analysis. Data are shown in percentages, and multivariable logistic regression was performed to determine predictive factors for benign pathology. Results: 3409 cases were analyzed, of which 403 (12%) were benign and 3006 (88%) malignant. Subtype analysis showed 2126 (62%) cases of clear-cell RCC, followed by 604 (18%) of papillary RCC and 344 (10%) oncocytomas. Mean age was 63 years among patients with malignant pathology versus 65 years for patients with benign lesions (p < 0.001). Mean tumor size was 3.2 cm for malignant pathology and 2.9 cm for benign (p < 0.001). The rates of benign and malignant pathology did not change between 2014 and 2022 (p = 0.377). Multivariable regression showed age ≥ 65 years (65–79 years [OR 1.881, p = 0.002], ≥ 80 years [OR 3.642, p < 0.001]) and tumor size (OR 0.793, p < 0.001) as predictors for benign pathology. The main limitation of this study is that we do not know the biopsy rate of our cohort. Conclusion: This study reports a low rate of 12% benign pathology after partial nephrectomy in the Netherlands. It remains debatable whether these rates are acceptable, or if renal tumor biopsies should be utilized more frequently to reduce overtreatment. Full article
(This article belongs to the Special Issue Optimizing Surgical Procedures and Outcomes in Renal Cancer)
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10 pages, 243 KiB  
Article
Perioperative and Oncological Outcomes of Percutaneous Radiofrequency Ablation versus Partial Nephrectomy for cT1a Renal Cancers: A Retrospective Study on Groups with Similar Clinical Characteristics
by Milosz Jasinski, Przemyslaw Wisniewski, Marta Bielinska, Jerzy Siekiera, Krzysztof Kamecki and Maciej Salagierski
Cancers 2024, 16(8), 1528; https://doi.org/10.3390/cancers16081528 - 17 Apr 2024
Viewed by 1337
Abstract
Over the recent years, progress in imaging techniques has led to an increased detection of kidney tumours, including small renal masses. While surgery is still the standard of care, there is a growing interest in minimally invasive methods. Ultrasound (US)-guided percutaneous ablation is [...] Read more.
Over the recent years, progress in imaging techniques has led to an increased detection of kidney tumours, including small renal masses. While surgery is still the standard of care, there is a growing interest in minimally invasive methods. Ultrasound (US)-guided percutaneous ablation is particularly attractive because it is a safe and relatively simple procedure. In this study, we investigated the results of US-guided percutaneous radiofrequency ablation (RFA) and partial nephrectomy (PN) in the treatment of cT1a renal cancers. Between August 2016 and February 2022, 271 patients with renal tumours underwent percutaneous RFA as initial treatment in our institution. In the same period, 396 patients with renal tumours underwent surgical tumour excision. For the purpose of this study, only patients with confirmed renal cancer with matched age and tumour characteristics (size, location) were selected for both groups. Thus, a group of 44 PN patients and 41 RFA patients were formed with the same qualification criteria for both groups. Parameters such as procedure length, blood loss, hospital stay, analgesics used, and pre- and post-procedural serum creatinine were compared between these groups. Patients followed up with contrast-enhanced CT. There was no significant difference in age, tumour size, tumour location, and creatinine levels between these groups. All procedures were generally well tolerated. During a median follow-up of 28 months, two cases of recurrence/residual disease were found in each group. The overall survival was 100% in both groups, and all patients were disease-free at the end of observation. Percutaneous RFA was associated with a significantly shorter procedure length and hospital stay, lower blood loss, and lower analgesics used than PN. In the selected group of renal cancer patients, US-guided percutaneous RFA was associated with a shorter hospital stay, less analgesics used, and a shorter procedure length than PN, without differences in the oncological results or kidney function. Full article
(This article belongs to the Special Issue Optimizing Surgical Procedures and Outcomes in Renal Cancer)
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