Immunotherapy of Cervical Cancer

Dear Colleagues,

Cervical cancer causes 528,000 new cases and 266,000 deaths worldwide every year, more than any other gynecological tumor, and is the fourth most common malignancy diagnosed in women. Although human papillomavirus (HPV) vaccines and cancer screenings have effectively decreased cervical cancer mortality in recent years, there is also an increasing demand for new therapeutic approaches to incurable metastatic cervical cancer, which cannot be treated with surgery or radiation.

Cervical cancer is closely linked to the persistent infection of carcinogenic HPV, which express viral oncogenes, causing the enhancement of genomic instability, accumulation of somatic mutations accumulation, then trigger immune system defects in cancer progress. Among these carcinogenic HPV types, the association with tumor risk and histological subtypes varies substantially, but the reasons for these differences remain elusive. Besides, therapeutic approaches for HPV-negative gastric type cervical cancer are needed in Asian countries.

A comprehensive understanding of tumor immunology has a certain promoting effect on the treatment of cervical cancer. Immune therapy including, but not limited to, the immune checkpoint blockade (ICB), adoptive cell transfer, therapeutic vaccines and cytokine treatment, has become a promising breakthrough in cancer treatment. This Special Issue will highlight the current state of tumor immunity in cervical cancer in all its diversity, covering both basic and (pre-)clinical aspects, advancing our knowledge to improve cervical cancer treatment.

Dr. Takashi Iwata
Guest Editor

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