Lectins in Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Metastasis".
Deadline for manuscript submissions: 25 May 2025 | Viewed by 1335
Special Issue Editors
Interests: collectins; ficolins; complement activation
Special Issue Information
Dear Colleagues,
Lectins are produced by bacteria, protists, fungi, plants, invertebrates, and vertebrates. They are classified into a variety of families, depending on host, structure, and function. Their carbohydrate/glycoconjugate recognition is a ubiquitous mode of molecular interactions and signalling. Neoplastic transformation is associated with, among other things, alterations in the cell surface. Due to an abnormal glycosylation pattern, cancer cells may be recognised by endogenous defence lectins, which may contribute to their elimination. On the other hand, they possess a variety of mechanisms of escape from a host’s immunity. Furthermore, cancer cells may employ lectins to facilitate metastatic spread. The specific recognition of cancer antigens by exogenous lectins makes possible their usage in diagnostics and therapy.
This Special Issue will be focused on the multiway associations of lectins with cancer, including primarily the following:
- Lectins in anti-cancer defence.
- Lectins in cancer diagnostics and treatment.
- Involvement of lectins in the epithelial to mesenchymal transition and metastasis.
- Expression of lectins in cancer (cancer cells, the tumour microenvironment, and hosts in general).
- Interactions of lectins with cancer cells.
- Interactions of lectins with oncogenic pathogens.
- Contribution of lectins to chronic inflammation.
- Cancer sugar code.
Prof. Dr. Maciej Cedzyński
Prof. Dr. Anna S. Świerzko
Guest Editors
Manuscript Submission Information
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Keywords
- lectin
- sugar code
- epithelial to mesenchymal transition (EMT)
- metastasis
- complement
- oncogenic pathogen
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