Radiomics in Cancer Imaging: Theory and Applications in Solid Tumours

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Causes, Screening and Diagnosis".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 454

Special Issue Editors


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Guest Editor
Department of Engineering, Università degli Studi di Perugia, Perugia, Italy
Interests: artificial intelligence; computational imaging; computer vision; image processing; medical image analysis; radiomics
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Section of Nuclear Medicine and Health Physics, Department of Medicine and Surgery, Università degli Studi di Perugia, Italy
Interests: nuclear medicine; image-based diagnostics; artificial intelligence; PET/CT; SPECT; SPECT/CT; radiomics; oncology; neurodegenerative disorders
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Radiomics is an approach to medical imaging that is aimed at extracting quantitative features that would otherwise go unnoticed to the human eye. By leveraging artificial intelligence and machine learning algorithms, radiomics can generate prediction models capable of assisting medical professionals in clinical decision-making. In this context, radiomics has attracted increasing worldwide interest as a potential tool for diagnosis, risk stratification, and treatment planning. Yet the translation of radiomics into clinical practise still faces some major hurdles, such as standardisation and reproducibility problems, lack of data for training the models, man-machine interaction issues (e.g., interpretability and willingness to accept the results of an algorithm), as well as legal and ethical issues. Radiomics is also a strongly multidisciplinary discipline, and its success depends a great deal on the cooperation of experts from different fields, including physicians, biologists, mathematicians, statisticians, computer scientists, and engineers.

This Special Issue wants to provide a forum to discuss challenges, discoveries, and opportunities of radiomics in the field of solid tumours. We welcome both methodological and application-oriented contributions. We encourage the submission of original research articles, reviews, and comparative evaluations.

Dr. Francesco Bianconi
Dr. Barbara Palumbo
Guest Editors

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Keywords

  • radiomics for the diagnosis, prognostication and treatment planning of solid tumours
  • methods, translational research and clinical applications
  • conventional and deep learning radiomics
  • interpretability of radiomics features and prediction models
  • image processing (including acquisition, segmentation and feature extraction)
  • imaging methods (including CT, MRI, PET, SPECT and US)

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Published Papers (1 paper)

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Review

34 pages, 2945 KiB  
Review
Radiogenomic Landscape of Metastatic Endocrine-Positive Breast Cancer Resistant to Aromatase Inhibitors
by Richard Khanyile, Talent Chipiti, Rodney Hull and Zodwa Dlamini
Cancers 2025, 17(5), 808; https://doi.org/10.3390/cancers17050808 - 26 Feb 2025
Viewed by 119
Abstract
Breast cancer poses a significant global health challenge and includes various subtypes, such as endocrine-positive, HER2-positive, and triple-negative. Endocrine-positive breast cancer, characterized by estrogen and progesterone receptors, is commonly treated with aromatase inhibitors. However, resistance to these inhibitors can hinder patient outcomes due [...] Read more.
Breast cancer poses a significant global health challenge and includes various subtypes, such as endocrine-positive, HER2-positive, and triple-negative. Endocrine-positive breast cancer, characterized by estrogen and progesterone receptors, is commonly treated with aromatase inhibitors. However, resistance to these inhibitors can hinder patient outcomes due to genetic and epigenetic alterations, mutations in the estrogen receptor 1 gene, and changes in signaling pathways. Radiogenomics combines imaging techniques like MRI and CT scans with genomic profiling methods to identify radiographic biomarkers associated with resistance. This approach enhances our understanding of resistance mechanisms and metastasis patterns, linking them to specific genomic profiles and common metastasis sites like the bone and brain. By integrating radiogenomic data, personalized treatment strategies can be developed, improving predictive and prognostic capabilities. Advancements in imaging and genomic technologies offer promising avenues for enhancing radiogenomic research. A thorough understanding of resistance mechanisms is crucial for developing effective treatment strategies, making radiogenomics a valuable integrative approach in personalized medicine that aims to improve clinical outcomes for patients with metastatic endocrine-positive breast cancer. Full article
(This article belongs to the Special Issue Radiomics in Cancer Imaging: Theory and Applications in Solid Tumours)
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