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Cancers
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Mechanisms of the cGAS-STING Pathway and Their Potential as Novel...
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Mechanisms of the cGAS-STING Pathway and Their Potential as Novel Targets for Immuno-Oncology

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".

Deadline for manuscript submissions: closed (10 March 2024) | Viewed by 2051

Special Issue Editor

Dr. Dong Zhang

E-Mail Website
Guest Editor
Department of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, NY 11568, USA
Interests: DNA damage response; DNA repair; telomere biology and alternative lengthening of telomeres (ALT); ALT cancers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Immuno-oncology (IO) has revolutionized cancer therapy in the last decade. The IO strategies currently approved by the FDA include the use of immune checkpoint inhibitors and chimeric antigen receptor (CAR) T cells. Recent studies have established a strong connection between DNA damage response/DNA repair and IO, for the following reasons. First, certain DNA damage response/DNA repair-related molecular and genetic features manifested by tumors, including elevated mutational burden, microsatellite instability (MSI), and mismatch repair deficiency (dMMR), have been used as biomarkers for immuno-oncology. Second, when unrepaired DNA fragments are released into cytosol, they induce the innate immune response through the activation of the cGAS-STING pathway. Third, at present, the agonists of the cGAS-STING pathway are being actively exploited as a novel form of immuno-oncology therapy.

The major aims of this Special Issue are:

(1) to elucidate the molecular mechanisms of how damaged DNA activates the cGAS-STING pathway;

(2) to target the cGAS-STING pathway as a novel immuno-oncology strategy.

I look forward to receiving your contributions.

Dr. Dong Zhang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cGAS
  • STING
  • DNA damage
  • immuno-oncology
  • molecular mechanisms

Published Papers (1 paper)

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Research

14 pages, 2073 KiB  
Article
Elevated Tumor Cell-Intrinsic STING Expression in Advanced Laryngeal Cancer
by Jelena Viculin, Marina Degoricija, Katarina Vilović, Ivana Gabela, Lucija Franković, Eduard Vrdoljak and Jelena Korac-Prlic
Cancers 2023, 15(13), 3510; https://doi.org/10.3390/cancers15133510 - 5 Jul 2023
Cited by 2 | Viewed by 1561
Abstract
Laryngeal cancer is the second most common malignancy of the head and neck, worldwide. Immunotherapy targeting checkpoint inhibitors has been approved for the treatment of patients with recurrent or metastatic laryngeal cancer but has a relatively low response rate and outcomes that leave [...] Read more.
Laryngeal cancer is the second most common malignancy of the head and neck, worldwide. Immunotherapy targeting checkpoint inhibitors has been approved for the treatment of patients with recurrent or metastatic laryngeal cancer but has a relatively low response rate and outcomes that leave many patients underserved. Targeting the cGAS–STING signaling pathway can potentially improve the activation of immune effector cells, although its role in the development and progression of laryngeal cancer has not yet been investigated in depth. Fifty-nine tumor samples from patients with pathologically confirmed squamous cell carcinoma of the larynx, stage I–IV non-metastatic disease, who were treated at the University Hospital of Split, were immunohistochemically stained for the expression of STING, cGAS, CD8, CD68, and CD163. Elevated tumor cell-intrinsic STING expression was positively associated with stage IV (p = 0.0031), pT3, and pT4 laryngeal cancers (p = 0.0336) as well as with higher histological grades (G2 and G3) (p = 0.0204) and lymph node-positive tumors (p = 0.0371). After adjusting for age, sex, location, and cGAS expression, elevated STING expression was significantly associated with stage IV cancer in a multiple logistic regression model (β = 1.849, SE = ±0.8643, p = 0.0324). Elevated STING expression represents a potentially favorable predictive biomarker for new therapeutic approaches involving STING agonists combined with immunotherapy and DNA-damaging agents (radiotherapy, cisplatin, and PARP inhibitors) in laryngeal cancer. Full article
(This article belongs to the Special Issue Mechanisms of the cGAS-STING Pathway and Their Potential as Novel Targets for Immuno-Oncology)
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