The Influence of Epigenetic Regulation on the Tumor Microenvironment: Mechanisms and Therapeutic Implications
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: 30 September 2025
Special Issue Editor
Interests: cancer epigenetics; molecular pathways; epi-drugs; genetic mutations; genetic engineering; targeted therapy; next-generation sequencing; tumor microenvironment
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Epigenetic modifications play a pivotal role in shaping the behavior of cells within the tumor microenvironment (TME), influencing various cellular processes that are crucial for tumor progression and immune evasion. By modulating core gene expression, these modifications can lead to the dysregulation of neoplastic cells, thereby promoting carcinogenesis. One significant impact of epigenetic changes is on the immune cells within the TME, where they can either suppress immunosuppressive cells or activate anti-cancer T effector cells, thus altering the immune landscape of the tumor. Epi-therapeutic strategies have emerged as promising interventions that may offer distinct advantages over traditional therapies such as chemotherapy and radiotherapy, by specifically targeting epigenetic alterations to modulate the TME more effectively. These strategies not only aim to normalize the phenotypes of cells within the TME, but also repress immunosuppressive factors, thereby potentially improving the overall prognosis and therapeutic outcomes for cancer patients. This Special Issue invites the submission of original research articles or comprehensive reviews that focus on enhancing our comprehension and manipulation of epigenetic modifications within the tumor microenvironment, a critical aspect in the development of effective cancer therapies.
Dr. Mariarosaria Conte
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- tumor microenvironment
- epigenetics
- cancer
- immune system
- remodeling mechanisms
- therapy
- clinical application
