Preclinical Models of Solid Malignancies
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 30889
Special Issue Editors
2. Department of Surgery, Faculty of Medicine Mannheim, University of Heidelberg, Heidelberg, Germany
Interests: circulating tumor cells; preclinical models of cancer; minimal residual disease; gastrointestinal cancer; lung cancer; surgical oncology; gastrointestinal surgery; thoracic surgery; pleural malignancy
Interests: pancreatic cancer; CRISPR/Cas; diagnosis; therapy; Kras; apoptosis
Special Issues, Collections and Topics in MDPI journals
Interests: dormancy; latency; diseminated tumor cells; minimal residual disease; chorioallantoic membrane model; CAM; preclinical models of cancer; metastasis; colorectal cancer; gastrointestinal cancer; surgical oncology; gastrointestinal surgery
Special Issue Information
Dear Colleagues,
Model systems are indispensable research tools in natural sciences. In cancer research, cell lines and xenograft mouse models have been the gold standard for many decades. However, the astonishingly low clinical approval rate of preclinically active compounds has made it clear that traditional, cell-line based tumor models are unable to accurately simulate the complex human disease.
In consequence, a multitude of novel tumor models have been developed in the past decade,; ranging from novel cell culture methods such as organoid culture or ex -vivo perfusion of tissue slices to avian chorioallantoic membrane (CAM) and sophisticated new animal models. Novel genetically engineered mouse models (GEMMs) of solid malignancies have been introduced in the past years and allow new insights into tumor biology as well as treatment experiments. While for the majority of solid tumors, GEMMs are now available, more tailored models for specific cancer subtypes are often still lacking. Moreover, in other malignancies (e.g., esophageal cancer), genetically engineered mouse models are still to be introduced.
Each tumor model has specific advantages and limitations, and some models are more suitable for clinical translation in a precision medicine setting than others. However, if carefully selected, novel tumor models enable cancer researchers to address their scientific questions with high accuracy and predictive power. This Special Issue will highlight the current state of the art, covering all aspects of preclinical tumor modeling in order to advance our understanding of solid tumors and their treatment.
Prof. Sebastian Schölch
Prof. Dr. Christian Pilarsky
Dr. Georg Flügen
Guest Editors
Manuscript Submission Information
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Keywords
- preclinical tumor models
- organoids
- 3D cell culture
- CAM model
- genetically engineered mouse models
- animal model
- solid malignancy
- orthotopic mouse model
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