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Epidemiology of Cancer and Risk Factors: Pushing Boundaries in Public...
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Epidemiology of Cancer and Risk Factors: Pushing Boundaries in Public Health Research and Policy

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Epidemiology and Prevention".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 1140

Special Issue Editor

Dr. The Phuong Nguyen

E-Mail Website
Guest Editor
1. Research Center for Health Policy and Economics, Hitotsubashi Institute for Advanced Study (HIAS), Hitotsubashi University, 2 Chome-1 Naka, Kunitachi 186-8601, Tokyo, Japan
2. Institute for Cancer Control, National Cancer Center Japan, 5 Chome-1-1 Tsukiji, Chuo City 104-0045, Tokyo, Japan
Interests: data science; epidemiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cancer remains the leading cause of death globally, driven by population aging, environmental exposures, and high-risk behaviors. Understanding the epidemiology of cancer and its risk factors is vital for developing targeted strategies for prevention, early detection, and intervention to address this pressing public health challenge. Despite significant progress, critical gaps persist in understanding the complex interplay of genetic, behavioral, and environmental factors influencing cancer incidence, mortality, and prevalence.

This Special Issue aims to advance research in cancer epidemiology, emphasizing novel methodologies, interdisciplinary approaches, and actionable insights to inform public health policy and practice. By addressing these gaps, it seeks to promote innovative strategies for prevention, detection, and management, contributing to a deeper understanding of cancer etiology and solutions to reduce the global cancer burden.

We are pleased to invite you to contribute to this Special Issue, welcoming original research on cancer epidemiology, innovative methodologies, interdisciplinary approaches, and policy analyses relevant to cancer prevention, early detection, and management. High-quality systematic reviews and clinical studies that offer valuable insights into this critical area of public health are also encouraged.

We look forward to your valuable contributions.

Dr. The Phuong Nguyen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer epidemiology
  • risk factors
  • public health policy
  • cancer prevention
  • early detection
  • genetic determinants
  • environmental exposures
  • behavioral health
  • interdisciplinary approaches
  • innovative methodologies

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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14 pages, 579 KiB  
Article
Cancer and Pregnancy: Update of Estimates in Italy by Linking Data from Cancer Registries and Hospital Discharge Records
by Daniela Pierannunzio, Alice Maraschini, Tania Lopez, Serena Donati, Edoardo Corsi Decenti, Paola Ballotari, Francesca Bella, Fortunato Bianconi, Ettore Bidoli, Rossella Bruni, Claudia Cirilli, Rosa Pasqualina De Vincenzo, Giovanna Fantaci, Giuseppe Furgiuele, Silvia Iacovacci, Antonella Ippolito, Lucia Mangone, William Mantovani, Elisabetta Merlo, Michael Mian, Walter Mazzucco, Maria Teresa Pesce, Giuseppe Sampietro, Giovanni Scambia, Fabrizio Stracci, Antonina Torrisi, Maria Francesca Vitale, Manuel Zorzi and Silvia Francisciadd Show full author list remove Hide full author list
Cancers 2025, 17(7), 1230; https://doi.org/10.3390/cancers17071230 - 5 Apr 2025
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Abstract
Background/Objectives: The increasing incidence of cancer during pregnancy is a growing public health concern, driven by delayed parenthood and rising maternal age. Pregnancy-associated cancer (PAC) presents complex clinical challenges, necessitating a balance between maternal cancer treatment and fetal safety. Historically considered incompatible [...] Read more.
Background/Objectives: The increasing incidence of cancer during pregnancy is a growing public health concern, driven by delayed parenthood and rising maternal age. Pregnancy-associated cancer (PAC) presents complex clinical challenges, necessitating a balance between maternal cancer treatment and fetal safety. Historically considered incompatible with favorable pregnancy outcomes, evidence now suggests that pregnancy can often proceed without affecting cancer prognosis. A 2022 study in Italy provided the first population-based PAC estimates by linking cancer registries (CRs) and hospital discharge records (HDRs). This study aimed to update PAC estimates to 2019, covering 30% of the Italian population and addressing prior data limitations. Methods: A retrospective longitudinal analysis was conducted on women aged 15–49 diagnosed with malignant cancers between 2003 and 2019. Data from 21 Italian CRs were linked with HDRs to identify PAC cases, defined as obstetric hospitalizations occurring for women diagnosed with cancer in our study cohort in the period spanning from one year before to two years after a cancer diagnosis. All malignant cancers, excluding non-melanoma skin cancers, were analyzed. PAC rates were calculated per 1000 pregnancies, and trends were assessed using log-linear and JoinPoint regression models. Results: Among 131,774 women diagnosed with cancer, 6329 PAC cases were identified, with a PAC rate of 1.43 per 1000 pregnancies, consistent with global estimates. Thyroid (24.4%) and breast cancer (23.2%) were the most common. Analyzing the PAC rate by pregnancy outcome, in the period 2015–2019, this increased for both childbirths and miscarriages but decreased for voluntary terminations. Most hospitalizations (54%) occurred pre-diagnosis, peaking at diagnosis, especially for breast cancer (69%). Conclusions: PAC incidence is rising, particularly for live births and miscarriages, underscoring the need for multidisciplinary care and robust epidemiological insights to guide clinical management. Full article
(This article belongs to the Special Issue Epidemiology of Cancer and Risk Factors: Pushing Boundaries in Public Health Research and Policy)
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17 pages, 611 KiB  
Article
Understanding Cervical Cancer Screening Attendance: Barriers and Facilitators in a Representative Population Survey
by Bogdan Florin Covaliu, Alina Ioana Forray, Mirela Tomic, Cătălin Vlad, Patriciu Achimaș Cadariu, Carmen Ungurean and Adriana Melnic
Cancers 2025, 17(4), 706; https://doi.org/10.3390/cancers17040706 - 19 Feb 2025
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Abstract
Background/Objectives: Cervical cancer causes high mortality rates globally despite the existence of cervical cancer screening. The purpose of this study is to investigate the factors limiting Romanian women’s participation in cervical cancer screening, focusing on socio-demographic characteristics, health practices, sexual history, and [...] Read more.
Background/Objectives: Cervical cancer causes high mortality rates globally despite the existence of cervical cancer screening. The purpose of this study is to investigate the factors limiting Romanian women’s participation in cervical cancer screening, focusing on socio-demographic characteristics, health practices, sexual history, and personal health views. Methods: A cross-sectional study was conducted with a representative sample of 1605 women aged 25 to 64 from all regions of Romania. Computer-Assisted Telephone Interviewing was performed in February and March 2020. Logistic regression models assessed the impact of socio-demographic characteristics, psychosocial factors, sexual health history, and personal beliefs on non-participation, which were quantified using the odds ratio. Results: A percentage of 25.1% of women had never been screened for cervical cancer. Higher education and income levels were linked to higher screening rates. The adjusted odds for a lack of HPV awareness were significantly high (aOR: 2.45, 95% CI: 1.85–3.25), highlighting a gap in health knowledge affecting screening behavior. Not receiving a referral to a specialist from the primary care physician (aOR: 2.96, 95% CI: 2.09–4.19) was strongly associated with increased odds of non-participation. Personal beliefs about cancer prevention, health misconceptions, perceived costs, and stigma emerged as significant contributors to cervical cancer screening participation. Conclusions: Analyzing predictors influencing participation in cervical screening is crucial for public health in Romania, which has high cervical cancer mortality and low participation rates in cervical cancer screening. To improve participation, we recommend enhanced physician referrals, HPV awareness campaigns, addressing social stigma, and widespread communication about screening availability. Full article
(This article belongs to the Special Issue Epidemiology of Cancer and Risk Factors: Pushing Boundaries in Public Health Research and Policy)
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