Neoadjuvant Chemotherapy for Breast Cancer

Dear Colleagues,

One of the scientific backgrounds of neoadjuvant chemotherapy is the hypothesis that earlier treatment with the eradication of subclinical micrometastasis will improve survival. The pioneering clinical trials by the I-SPY2 working group have successfully identified the therapeutic agents through pCR improvement and established the "response predictor subtype".

Still, there are a lot of unresolved issues regarding the neoadjuvant chemotherapy of breast cancer, such as the predictor of pCR, the best sequence of the therapeutic regimen, the effective treatment of non-pCR patients, the role of conventional chemotherapy in terms of immunological effect, de-escalation after pCR, and escalation therapy for non-pCR. To breast surgeons, the extent of breast surgery and the efficacy of sentinel node biopsy after NAC and the best strategy for axillary management after nodal pCR are still controversial.

Through the Special Issue titled "Neoadjuvant Chemotherapy for Breast Cancer" of Cancers, all experts in this field are invited to contribute and submit their papers in an attempt to resolve the above issues.

Dr. Shin-Cheh Chen
Guest Editor

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