RASSF Signalling in Cancer
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (15 December 2015) | Viewed by 51200
Special Issue Editor
Interests: RASSF signalling; DNA methylation in cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The Ras Association Domain Family (RASSF) consists of ten members, which encode either a C-Terminal Ras association (RA) domain or a N-terminal RA. Most of the RASSF are tumor suppressor genes that are frequently epigenetically inactivated in human cancers. Functional studies have shown that RASSF signaling is involved in several pathways including Ras and Hippo. Deregulation of the RASSF members alters cell cycle control, growth and apoptosis of cancer cells. Thus aberrant RASSF signaling plays a key role in the pathogenesis of human cancers. In this special issue of cancers we invite you to submit an original manuscript analyzing the function or epigenetic alteration of the RASSF members in cancers.
Prof. Dr. Reinhard Dammann
Guest Editor
Manuscript Submission Information
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Keywords
- ras Association Domain Family
- N-Terminal RASSF
- C-Terminal RASSF
- cancer
- epigenetic regulation
- DNA methylation
- tumor suppressor gene
- hippo pathway
- ras signaling
- apoptosis
- cell cycle regulation
- growth inhibition
- DNA repair
- genetic alterations
- biomarker
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