Tumor Microenvironment in Breast Cancers
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".
Deadline for manuscript submissions: closed (20 July 2022) | Viewed by 2765
Special Issue Editor
Interests: tumor microenvironment; breast cancer; metastasis; mesenchymal stem cells; MSCs; cancer stem cells; CSCs; microRNAs; long non-coding RNAs; lncRNAs; cancer stroma
Special Issue Information
Dear Colleagues,
Neoplastic epithelial cells within breast cancers co-exist with a variety of stromal cell types that collectively form the tumor microenvironment (TME). It is increasingly appreciated that such stromal niche is not an inert bystander of tumor development, but an active participant in several aspects of cancer pathogenesis, be they initiation, growth, or progression. Indeed, mounting research studies have catalogued the heterotypic interactions that operate between breast cancer cells and their microenvironment and have enumerated critical influences of such crosstalk, for example, on cancer stem cell (CSC) genesis, metabolic adaptation, clonal expansion and heterogeneity, or immune evasion. Equally compelling is evidence describing the regulatory impact of the TME on cancer cell invasion, spread, and response to therapy. While much has been learnt on these fronts over the past few decades, our understanding of the contributions of the TME to breast malignancy is far from complete and deserves further focus. This Special Issue of Cancers will highlight the essential role of the TME in breast cancer development and is intended to encompass both basic and translational research articles that would further expand our understanding of the contextual stromal signals that steer breast cancer pathogenesis and provide novel avenues for disease management in the clinic.
Dr. Antoine E. Karnoub
Guest Editor
Manuscript Submission Information
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Keywords
- breast cancer
- tumor microenvironment
- stroma
- TME
- cancer therapy
