Application of Large-Scale Genome Data in Identifying Clinically Actionable Targets in Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".

Deadline for manuscript submissions: 15 June 2025 | Viewed by 1

Special Issue Editor


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Guest Editor
Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA
Interests: precision oncology; clinical genomics
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Special Issue Information

Dear Colleagues,

Large-scale data analysis has contributed tremendously to precision oncology. Genome data analysis has enabled the identification of signature tumor profiles in selective cancers. Many of these targets (e.g., tumor burden or MSI) have therapeutic or diagnostic applications. Separately, large-scale data analysis in constitutional cancer has enabled the identification of alterations related to cancer risk and familial cancer.

This Special Issue provides a platform for studies that utilize large-scale genome data to investigate clinically actionable targets in tumors (i.e., somatic) or germline (i.e., constitutional) cancer. We welcome manuscripts that include large data analysis to present novel methods to identify validated clinical targets in the genome, novel actional variants in selected cancer types (somatic or inherited cancer), functional analysis of genomics and genome targets, analysis of multi-omics data, cancer cohort analysis, variant pattern recognition analysis, and applications of machine learning and AI in identifying actional clinical targets.

Dr. Arezou A. Ghazani
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • genome
  • cancers
  • oncology

Published Papers

This special issue is now open for submission.
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