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Cancers
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Surgery for Colorectal Cancer
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Surgery for Colorectal Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 1901

Special Issue Editors

Prof. Dr. Antonio V. Sterpetti

E-Mail Website
Guest Editor
Department of Surgery “Pietro Valdoni”, University of Rome, 00161 Rome, Italy
Interests: inflammation and cancer; aging and cancer; robotic surgery for colorectal cancer; screening for colorectal cancer
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Raimondo Gabriele

E-Mail Website
Guest Editor
Department of Surgery “Pietro Valdoni”, University of Rome, 00161 Rome, Italy
Interests: inflammation and cancer; aging and cancer; robotic surgery for colorectal cancer; screening for colorectal cancer

Special Issue Information

Dear Colleagues,

Colorectal cancer (CRC) commonly metastasizes; approximately 50% of patients with CRC develop metastasis. Despite advancements in therapy and surgery, the 5-year overall survival rate of patients with CRC metastasis is below 40%.

This Special Issue welcomes contributions in the form of original research papers and reviews that cover the following themes:

  • Novel therapeutic approaches targeting metastasis from CRC;
  • Preclinical experimental models studying metastasis from CRC;
  • Translational studies related to metastasis from CRC;
  • Novel methodological approaches and advances in software tools improving the phenotypic and molecular characterization of metastasis from CRC;
  • Methods to improve education and information to reduce socio-economic disparities in colon–rectal cancer screening;
  • Clinical and oncologic outcomes after robotic surgery for colon–rectal cancer;
  • Clinical and oncologic outcomes for minimally invasive surgery for localized colon and rectal cancer.

Prof. Dr. Antonio V. Sterpetti
Prof. Dr. Raimondo Gabriele
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • clinical and oncologic outcomes after new forms of therapy for colon–rectal cancer
  • colon cancer
  • rectal cancer
  • colorectal cancer

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Published Papers (3 papers)

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Research

13 pages, 2041 KiB  
Article
Education and Information to Improve Adherence to Screening for Breast, Colorectal, and Cervical Cancer—Lessons Learned during the COVID-19 Pandemic
by Raimondo Gabriele, Monica Campagnol, Paolo Sapienza, Valeria Borrelli, Luca Di Marzo and Antonio V. Sterpetti
Cancers 2024, 16(17), 3042; https://doi.org/10.3390/cancers16173042 - 31 Aug 2024
Viewed by 426
Abstract
The objective of this study was to determine the correlation between adherence to cancer screening programs and earlier diagnosis of the 14 most common types of cancers in the adult population, before and during the COVID-19 pandemic. National data concerning number of admissions [...] Read more.
The objective of this study was to determine the correlation between adherence to cancer screening programs and earlier diagnosis of the 14 most common types of cancers in the adult population, before and during the COVID-19 pandemic. National data concerning number of admissions and operations in Italy for adult patients admitted with oncologic problems during the COVID-19 pandemic (2020 to 2022) and in the pre-pandemic period (2015 to 2019) were analyzed. We selected 14 types of cancer that present the most common indications for surgery in Italy. This study included 1,365,000 adult patients who had surgery for the 14 most common types of cancer in the period 2015–2022, and interviews concerning adherence rates to screening for breast, colorectal, and cervical cancer were conducted for 133,455 individuals. A higher decrease in the number of operations for the 14 types of cancer (−45%) was registered during the first three acute phases of the pandemic, and it was more evident for screenable cancers like breast, colorectal, and cervical cancer (p < 0.001). During the first year of the COVID-19 pandemic, the number of screened individuals for breast, colorectal, and cervical cancer decreased by 33.8% (from 7,507,893 to 4,969,000) and the number of diagnoses and operations for these three types of cancer decreased by 10.5% (from 107,656 to 96,405). The increase and return to normality of the number of screened individuals in the last year of the pandemic (2022) and in the first post-pandemic year (2023) was associated with a return to the pre-pandemic levels of diagnoses and operations. The adherence rates were lower for individuals living in rural areas, with low socio-economic status, and unmarried persons; however, the most statistically significant factor for reduced adherence was a lower level of educational attainment. Free screening through nationally organized programs reduced social disparities. There were no significant differences between the pre-pandemic and pandemic periods for several types of cancers (stomach, esophagus, pancreas, liver) that are diagnosed for the occurrence of symptoms and for which nationally organized programs might increase the possibility of earlier diagnosis and improved clinical outcomes. Education, information, and appropriate expenditure for preventive care have the potential to reduce cancer mortality. Nationally organized screening programs for several types of cancers, which are often detected for the occurrence of symptoms, may increase the possibility of diagnosis at earlier stages. Full article
(This article belongs to the Special Issue Surgery for Colorectal Cancer)
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11 pages, 837 KiB  
Article
Pre-emptive Laparoscopic Colostomy Creation in Obstructing Locally Advanced Rectal and Anal Cancer Does Not Delay the Starting of Oncological Treatments
by Giovanni Taffurelli, Isacco Montroni, Claudia Dileo, Alessandra Boccaccino, Federico Ghignone, Davide Zattoni, Giacomo Frascaroli and Giampaolo Ugolini
Cancers 2024, 16(16), 2799; https://doi.org/10.3390/cancers16162799 - 8 Aug 2024
Viewed by 478
Abstract
Background: Managing patients with obstructing rectal cancer is challenging due to the risks of gastrointestinal obstruction and perforation. This study evaluates the outcomes of pre-emptive laparoscopic colostomy creation in patients with locally advanced rectal and anal cancer to prevent symptoms and facilitate therapy [...] Read more.
Background: Managing patients with obstructing rectal cancer is challenging due to the risks of gastrointestinal obstruction and perforation. This study evaluates the outcomes of pre-emptive laparoscopic colostomy creation in patients with locally advanced rectal and anal cancer to prevent symptoms and facilitate therapy initiation. Methods: This retrospective cohort study includes patients with locally advanced rectal or anal cancer assessed by our Colorectal Multidisciplinary Team from January 2017 to February 2024. Patients who underwent pre-emptive laparoscopic colostomy were compared to a control group of non-obstructing rectal cancer patients who started direct oncological treatment. The primary endpoint was the time from diagnosis to the initiation of oncological treatments. The secondary endpoints were the rate and timing of subsequent radical resection, surgical morbidity and hospital stay. A Weibull regression was used to evaluate the time differences between the groups. Results: There were 37 patients who received pre-emptive laparoscopic colostomy, compared to 207 control patients. The mean time from diagnosis to the start of neoadjuvant therapy was 38.3 ± 2.3 days. Despite higher rates of malnutrition and more advanced stages in the colostomy group, no significant differences were observed in the time to start therapy (p = 0.083) or time to radical resection (p = 0.187) between the groups. The laparoscopic procedure showed low rates of postoperative complications and acceptable lengths of stay. Discussion and Conclusions: Pre-emptive laparoscopic colostomy is a feasible approach for managing obstructing rectal or anal cancer. Treatment timelines were not extended compared to timelines for non-obstructing cases, despite differences in nutritional status and staging. Further prospective studies with larger cohorts are needed to validate these findings and refine treatment protocols for obstructing gastrointestinal malignancies. Full article
(This article belongs to the Special Issue Surgery for Colorectal Cancer)
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11 pages, 2601 KiB  
Article
Colonic Adenosquamous Carcinoma: A Single-Center Review of Patient Clinicopathologic Characteristics, Genetics, and Clinical Outcomes
by David A. Lieb II, Hannah M. Thompson, Floris S. Verheij, Jinru Shia, Francisco Sanchez-Vega, Georgios Karagkounis, Maria Widmar, Iris H. Wei, J. Joshua Smith, Garrett M. Nash, Martin R. Weiser, Philip B. Paty, Andrea Cercek, Leonard B. Saltz, Julio Garcia-Aguilar and Emmanouil Pappou
Cancers 2024, 16(15), 2641; https://doi.org/10.3390/cancers16152641 - 25 Jul 2024
Viewed by 625
Abstract
(1) Background: Adenosquamous carcinoma (ASC) is a rare subtype of colon cancer. Its rarity makes characterization challenging, although colonic ASC is believed to present at more advanced stages and have worse outcomes versus adenocarcinoma. This study aims to characterize the clinicopathological characteristics and [...] Read more.
(1) Background: Adenosquamous carcinoma (ASC) is a rare subtype of colon cancer. Its rarity makes characterization challenging, although colonic ASC is believed to present at more advanced stages and have worse outcomes versus adenocarcinoma. This study aims to characterize the clinicopathological characteristics and clinical outcomes of colonic ASC. (2) Methods: This is a single-center, retrospective review of patients diagnosed with colonic ASC from 2000 to 2020. Data extracted included patient demographics, staging at diagnosis, tumor clinicopathologic and genetic characteristics, and clinical outcomes. (3) Results: Among 61,126 patients with colorectal cancer, 13 (0.02%) had colonic ASC, with a mean age at diagnosis of 48.7 years. The cecum/ascending colon was the most common primary site (6/13, 46.2%), and all except one patient was diagnosed with Stage III or IV disease. Among the eight patients with mismatch repair genetics available, only one was mismatch repair deficient. Eleven patients (84.6%) underwent surgery, and 11 likewise received some form of chemotherapy. Recurrence occurred in 7 of 13 patients (53.8%), and the overall five-year survival rate was 38.5%. The median survival rate was 39.4 months overall (30.5 months for Stage III, 23.7 months for Stage IV). (4) Conclusions: Overall, colonic ASC is rare, and this cohort of colonic ASC patients demonstrated advanced stage at diagnosis, frequent recurrence, and poor overall survival. Additional research remains to compare these characteristics with those of comparably staged adenocarcinoma and to develop specific management recommendations. Full article
(This article belongs to the Special Issue Surgery for Colorectal Cancer)
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