Clinical and Immunological Therapy for Solid Tumors

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".

Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 1788

Special Issue Editor


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Guest Editor
Department of Pediatrics Hematology/Oncology, Medical College of Georgia, Augusta, GA, USA
Interests: biobank; primary cell culture engineering; cell therapy; clinical genomics and diagnosis; single cell genomics

Special Issue Information

Dear Colleagues,

In recent years, immunotherapies for solid tumors have generated spectacular outcomes for cancer patients in clinics. Adoptive cell therapies (ACT), including using autologous tumor-infiltrating lymphocyte (TILs), TCR T-cells (TCR-engineered T cell), chimeric antigen receptor (CAR) T cells, tumor vaccines and checkpoint blockade, have emerged as the most effective treatments for solid tumors. The current challenge for solid cancer immunotherapies is that although some patients have benefited from these treatments, many cancers will still have variable responses. The purpose of this Special Issue is to understand the treatment advantages and disadvantages in order to provide exciting opportunities for effective anticancer immunotherapies for solid tumors. This Special Issue welcomes reviews, as well as original research articles, which should be submitted by 30 June 2024.

Dr. Biaoru Li
Guest Editor

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Keywords

  • TCR T cells, TIL
  • CAR T cells and tumor vaccines
  • immunotherapy and adoptive cell transfer
  • personalized immunotherapy and genomics analysis
  • T-cell homing which includes T-cell rolling, adhesion, extravasation, and chemotaxis into the solid tumor

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Published Papers (1 paper)

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Review

29 pages, 1618 KiB  
Review
B7H4 Role in Solid Cancers: A Review of the Literature
by Miriam Dawidowicz, Anna Kot, Sylwia Mielcarska, Katarzyna Psykała, Agnieszka Kula, Dariusz Waniczek and Elżbieta Świętochowska
Cancers 2024, 16(14), 2519; https://doi.org/10.3390/cancers16142519 - 11 Jul 2024
Viewed by 1430
Abstract
Anti-cancer immunotherapies entirely changed the therapeutic approach to oncological patients. However, despite the undeniable success of anti-PD-1, PD-L1, and CTLA-4 antibody treatments, their effectiveness is limited either by certain types of malignancies or by the arising problem of cancer resistance. B7H4 (aliases B7x, [...] Read more.
Anti-cancer immunotherapies entirely changed the therapeutic approach to oncological patients. However, despite the undeniable success of anti-PD-1, PD-L1, and CTLA-4 antibody treatments, their effectiveness is limited either by certain types of malignancies or by the arising problem of cancer resistance. B7H4 (aliases B7x, B7H4, B7S1, VTCN1) is a member of a B7 immune checkpoint family with a distinct expression pattern from classical immune checkpoint pathways. The growing amount of research results seem to support the thesis that B7H4 might be a very potent therapeutic target. B7H4 was demonstrated to promote tumour progression in immune “cold” tumours by promoting migration, proliferation of tumour cells, and cancer stem cell persistence. B7H4 suppresses T cell effector functions, including inflammatory cytokine production, cytolytic activity, proliferation of T cells, and promoting the polarisation of naïve CD4 T cells into induced Tregs. This review aimed to summarise the available information about B7H4, focusing in particular on clinical implications, immunological mechanisms, potential strategies for malignancy treatment, and ongoing clinical trials. Full article
(This article belongs to the Special Issue Clinical and Immunological Therapy for Solid Tumors)
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