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Cancers
Special Issues
Obesity and Cancers
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Obesity and Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Epidemiology and Prevention".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 1280

Special Issue Editors

Dr. Edward Sauter

E-Mail Website
Guest Editor
Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA
Interests: cancer prevention; obesity-related cancer; lifestyle approaches to prevent cancer
Dr. Tanya Agurs-Collins

E-Mail Website
Guest Editor
Health Behaviors Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, 9609 Medical Center Drive, Rockville, MD 20850, USA
Interests: obesity and cancer risk and control; lifestyle factors; diet and weight loss interventions; obesity and cancer disparities

Special Issue Information

Dear Colleagues,

This Special Issue aims to highlight the impact of obesity on cancer risk and control. Submissions should explore the biological, social, behavioral and environmental factors that impact obesity-related cancers. We welcome interventional studies and reviews related to strategies for obesity prevention and control, such as surgery, medications, lifestyle behavioral changes (diet and  physical activity to reduce obesity and subsequently cancer risk,  progression, and improve cancer survival). Studies focused on omics technologies that examine genetics, metabolomics, and the microbiome related to obesity and cancer are also encouraged.

Topics of interest include:

1. Which cancers are impacted by obesity?

2. What biological, social, behavioral and environmental factors drive obesity?

3. What are the mechanisms by which obesity aggravates (or ameliorates) cancer development and/or progression?

4. How does obesity impact cancer care, including cancer screening and treatment?

5. Role of genetics in obesity and cancer.

6. Impact of the gut microbiome on obesity and cancer.

7. Impact of race and gender on obesity and cancer.

8. Impact of weight loss interventions (bariatric surgery, weight loss medications, lifestyle changes, physical activity) on cancer risk and progression.

9. How do social determinants of health influence obesity-related cancer risk and poor outcomes?

10. What is the role of body composition (i.e., visceral fat) on cancer risk and treatment?

11. Which systemic and structural factors influence obesity-related cancer risk and health disparities?

Dr. Edward Sauter
Dr. Tanya Agurs-Collins
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obesity
  • cancer
  • mitigating factors
  • weight loss
  • weight gain
  • obesity interventions

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Published Papers (1 paper)

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Research

13 pages, 1640 KiB  
Article
Investigating the Obesity Paradox in Colorectal Cancer: An Analysis of Prospectively Collected Data in a Diverse Cohort
by Shria Kumar, Catherine Blandon, Alla Sikorskii, David E. Kaplan, Shivan J. Mehta, Grace L. Su, David S. Goldberg and Tracy E. Crane
Cancers 2024, 16(17), 2950; https://doi.org/10.3390/cancers16172950 - 24 Aug 2024
Viewed by 869
Abstract
Background: Prior studies are inconclusive regarding the effect of obesity on mortality in persons with colorectal cancer (CRC). We sought to determine the association of pre-diagnosis body mass index (BMI) trajectories on mortality after CRC diagnosis. Methods: Utilizing the Multiethnic Cohort, we included [...] Read more.
Background: Prior studies are inconclusive regarding the effect of obesity on mortality in persons with colorectal cancer (CRC). We sought to determine the association of pre-diagnosis body mass index (BMI) trajectories on mortality after CRC diagnosis. Methods: Utilizing the Multiethnic Cohort, we included adults aged 18–75 between 1 January 1993 and 1 January 2019 with a diagnosis of CRC and at least three available BMIs. The primary exposure, BMI, was subjected to group-based trajectory modeling (GBTM). We evaluated all-cause and CRC-specific mortality, using Cox proportional hazard (PH) models. Results: Of 924 persons, the median age was 60 years, and 54% were female. There was no statistically significant association between pre-cancer BMI trajectory and either all-cause or cancer-specific mortality. In competing risk analysis, the risk of CRC-specific mortality was higher for African Americans (HR = 1.56, 95% CI [1.00–2.43], p = 0.048) and smokers (HR = 1.59, 95% CI [1.10–2.32], p = 0.015). Risk of all-cause mortality was higher for Hawaiian persons (HR = 2.85, 95% CI [1.31–6.21], p = 0.009) and persons with diabetes (HR = 1.83, 95% CI [1.08–3.10], p = 0.026). Conclusions: Pre-diagnosis BMI trajectories were not associated with mortality after CRC diagnosis, whereas race/ethnicity, diabetes, and smoking were associated with an increased risk of death. Our findings suggest the obesity paradox alone does not account for mortality after CRC diagnosis. Full article
(This article belongs to the Special Issue Obesity and Cancers)
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