Clonal Evolution in Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 544
Special Issue Editors
Interests: chromosome instability; telomere dysfunction; cancer, continuous growth
Special Issues, Collections and Topics in MDPI journals
Interests: genome integrity; epigenetic regulation; gene expression; translation; viruses; molecular virology; viruses’ evolution
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
From the early steps of carcinogenesis up to the late stages of advanced malignancy, tumors undergo genetic and epigenetic changes that shape the natural history of the disease and dramatically affect therapy responses. Many cancers are initiated from a single cell affected by a combination of mutations that are sufficient and enough to drive continuous mitotic growth. However, due to chronic replication stress and inherent insufficiencies of DNA damage responses, the descendants of cancer progenitor cells tend to stochastically accumulate additional genetic and epigenetic alterations that are randomly dispersed between co-dividing cell populations. These reiterative genomic insults generate intratumor genetic heterogeneity, allowing the emergence of multiple subclones that are subjected to selection and adaptation. Intratumor polyclonality reflects phenotypic differences between cancer cells of monoclonal origin and underlies oncotherapy resistance. Current research in cancer clonal evolution moves from classical and molecular cytogenetics to single-cell multi-omics aided by highly powerful bioinformatics. This substantial progress allows to study multiple specimens from the same tumor, in animal models and in three-dimensional organoid cultures or patient-derived xenografts, clonal hierarchy and fitness, as well as autocrine and paracrine inter-clonal interactions and their relationship with the tumor microenvironment and the progression towards metastasis and aggressive malignancy.
This Special Issue of Cancers is dedicated to presenting advances in our understanding of intratumor natural selection through comprehensive reviews and original research articles on cancer clonal evolution written by experts in the field.
Dr. Sarantis Gagos
Dr. Theodoros Rampias
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer clonal evolution
- polyclonality
- intra-tumor genetic heterogeneity
- oncotherapy resistance
- single-cell multi-omics
- cytogenomics
- cancer subclones
- clonal complexity in cancer
- cancer clone dynamics
- clonal diversity
- clonal hierarchy
- clonal expansion
- epigenetics
- driver mutations
- passenger mutations
- clonal architecture
- sub-clonal segregation of mutations
- cancer cell fitness
- selective pressure
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