The Role of Molecular Medicine in the Targeted Treatment of Gastric Cancer
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 441
Special Issue Editors
Interests: Gastrointestinal Cancers; Helicobacter pylori; immunotherapy; myeloid derived suppressor cells; tumor associated macrophages; Hedgehog signaling; organoid technology; tumor microenvironment; CD44v9; cancer stem cells; hypoxia; PD-L1; mTOR signaling; HER2
Special Issue Information
Dear Colleagues,
Gastric cancer is the fifth most common cancer worldwide and the third most common cause of cancer-related death. The incidence of gastric cancer in the United States is relatively low due to the diagnosis and treatment of the major risk factor Helicobacter pylori (H. pylori). However, the 5-year survival rate for patients diagnosed with this malignancy is only 29%. H. pylori infects nearly 4.4 billion people and is the number one risk factor for gastric cancer. Classically, H. pylori is treated with antibiotics. Unfortunately, once a patient has progressed to a metaplastic phenotype, the elimination of H. pylori does not reduce the risk of developing gastric cancer. Gastric cancer is the final clinical outcome that is often initiated by a sustained inflammatory response to H. pylori infection, and immune cell-epithelial crosstalk.
While surgical resection is the preferred treatment, chemotherapy is used for recurrent and advanced gastric cancer patients. The 29% overall survival and lack of a standard chemotherapy regimen for cancer patients make studies identifying targeted treatment modalities a research priority for gastric cancer. Foundational science and clinical studies have elucidated the potential for molecular targeted therapy on various signaling mechanisms of gastric cancer, that include epidermal growth factor, angiogenesis, immune-checkpoint inhibition, cell cycle and apoptosis, c-Met, mTOR signaling, hypoxia and CD44v9. This Special Issue will highlight the in-depth understanding of the mechanisms that underlie molecular targeted therapies and new insights into gastric cancer treatment.
Prof. Dr. Yana Zavros
Prof. Dr. Jimmy Bok Yan So
Guest Editors
Manuscript Submission Information
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