Mitochondrial Functions in Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Epidemiology and Prevention".
Deadline for manuscript submissions: 1 October 2024 | Viewed by 21666
Special Issue Editors
Interests: tumor metabolism; hypoxia; angiogenesis; metastasis; chemoresistance; radioresistance; glycolysis; oxidative phosphorylation; lactate; mitochondrial reactive oxygen species (mtROS); translational research
Special Issues, Collections and Topics in MDPI journals
Interests: bioenergetics; targeting mitochondria in cancer; mitochondrial modulation and medicine; REDOX signaling; metabolic reprogramming
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mitochondria are bioenergetic organelles that are believed to originate from a symbiotic relationship established between archebacteria and the ancestors of eukaryotic cells. They comprise an outer and an inner membrane that delineate an intermembrane space, and an inner matrix hosting a short, circular DNA and several enzymes orchestrating, e.g., the tricarboxylic acid (TCA) cycle. Oxygen-dependent respiration for ATP production occurs at the electron transfer chain (ETC) localized at the inner mitochondrial membrane. Besides bioenergetics, mitochondria also control several other key cellular functions, comprising apoptosis, calcium homeostasis, iron metabolism and redox signaling. Their subcellular location changes depending on cell activities. Upon damage, their renewal involves mitochondrial selective autophagy (mitophagy) and mitochondrial biogenesis.
In tumors, cancer cells (and host cells) strive to simultaneously ensure optimal energy production and biosynthesis with local resources that are often limited. The balance between these activities depends on mitochondrial functions that can oscillate between ATP production and biosynthesis. Mitochondria also participate in cancer cell immortalization and may act as metabolic sensors of the tumor microenvironment. Upon treatment, they can be damaged and repaired, thus participating in resistance to therapy. This Topic issue in Cancers aims to address these functions, with a key interest for the relationship between mitochondria and specific phenotypic changes occurring during tumor growth and treatment.
Prof. Dr. Pierre Sonveaux
Prof. Dr. Rodrigue Rossignol
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer
- mitochondria
- mitochondrial DNA
- TCA cycle
- electron transport chain
- apoptosis
- calcium homeostasis
- mitophagy
- mitochondrial biogenesis
- fission
- fusion
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.