New Insights into Mast Cells Biology

Dear Colleagues,

Mast cells (MCs) are crucial effector cells in type I allergic reactions. Until recently, IgE was the best-known mechanism to trigger their degranulation and release of a vast array of allergic mediators. However, there are many more pathways for eliciting mast cell responses and there are many other mediators. Histamine is the most abundant mediator that is released; however, other cytokines can be of great immunological importance. Based on our current knowledge, one of the most important mast cell receptors is the recently uncovered Mas-related G protein-coupled receptor type 2 (MRGPRX2).

In this Special Issue of Cells entitled New Insights into Mast Cells Biology, we are inviting contributions in the form of original research articles, reviews, or shorter perspective articles on all aspects related to, but not limited to, the topics of mast cells development, IgE- and non-IgE-mediated MC activation, particularly via the MRGPRX2 receptor, the role of autoimmune reactions in mast cell-dependent diseases such as urticaria, and drugs that target mast cell survival and their potential adverse events.

Dr. Katarina Stevanovic
Prof. Dr. Torsten Zuberbier
Guest Editors

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