Hemoglobin and Other Globin Types: Structure, Function and Evolution

Dear Colleagues,

Globins are indisputably among the most studied proteins. Globins are heme-proteins, involved in different cellular functions via their reversible binding capacity to gaseous ligands and their storage, transport, and detoxification. Historically, the familiar vertebrate O₂-binding hemoglobin and myoglobin were among the first proteins whose sequences and structures were determined over 60 years ago. Most known globins fulfil respiratory functions, supplying the cell with adequate amounts of O₂ for aerobic energy production via the respiratory chain in the mitochondria. However, over the last two decades, evidence has accrued indicating that globins exhibit further novel functions as enzymes, sensors, and signalling molecules. In parallel, the post-genomic era also revealed the existence of several additional globin types including chimeric variants.

In this Special Issue, we welcome original research and review articles demonstrating the functional diversity of globins throughout all taxa. We specifically solicit contributions on novel functional, evolutionary, and structural aspects of globins, illustrating the physiological versatility of this protein superfamily.

Prof. Dr. David Hoogewijs
Dr. Luc Moens
Guest Editors

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