Adipocytes in the Pathogenesis of Autoimmune Rheumatic Diseases
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 1827
Special Issue Editors
Interests: adipose tissue; adipokines; anti-inflammatory foods; atherosclerosis; cardioprotective diets; lipids and lipidomic; metabolic diseases; nutrigenomics and nutrimiromics
2. Research Institute, Hospital do Coracao (HCor), Sao Paulo, Brazil
Interests: interstitial lung disease; pulmonary fibrosis; autoimmune rheumatic diseases; sub-phenotyping; disease progression
Special Issue Information
Dear Colleagues,
General and abdominal obesity can directly affect the immune system, and these changes can contribute to an increased susceptibility to autoimmune rheumatic diseases. Adipose tissue can become severely dysfunctional with excess increases in body weight, causing the accumulation of myeloid and lymphoid cells and changes in the extracellular matrix. Furthermore, there is an imbalance in the secretion of adipokines, increased levels of oxidative stress, and changes in the inflammatory state of immune cells infiltrating the adipose tissue itself—a situation that can be independently worsened by an unhealthy diet and sedentary lifestyle. Furthermore, the accumulation of excessive body fat can make it difficult to resolve disease-induced inflammation by increasing Th17 cell differentiation, decreasing T cells, and reducing the synthesis of TGF-beta, favoring the development of autoimmune diseases and contributing to their progression. This Special Issue of Cells invites researchers to contribute with original studies and review articles covering the state-of-art regarding experimental (in vitro and in vivo), preclinical, and translational research that enrich our understanding of the pathological role of dysfunctional adipocytes in the development and the progression of autoimmune diseases. Research fields include any aspect involving key cells, molecular pathways, and molecular interactions, including strategies for the prevention and treatment of adiposity-targeted autoimmune rheumatic diseases.
Dr. Aline Marcadenti
Dr. Letícia Barbosa Kawano-Dourado
Guest Editors
Manuscript Submission Information
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Keywords
- adipose tissue
- adipokines
- autoimmune rheumatic diseases
- antibodies
- citokines
- inflammation
- imunometabolism
- pulmonary fibrosis
- interstitial lung disease
