Emerging Therapies for Hereditary Ataxia—Second Edition
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (25 June 2025) | Viewed by 1435
Special Issue Editors
Interests: neuroanatomy of cerebellar ataxia; modulators of oxidative stress; functional food
Special Issues, Collections and Topics in MDPI journals
Interests: neurogenetics; neurodegeneration; neurodevelopment
Special Issues, Collections and Topics in MDPI journals
Interests: neurodegenerative diseases; neurodevelopment; oxidative stress
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We invite the submission of original research and review articles for a Special Issue titled “Emerging Therapies for Hereditary Ataxia—Second Edition”. Hereditary ataxia (HA) represents a group of genetically heterogeneous neurodegenerative diseases. It can be classified by the pattern of inheritance: autosomal dominant, autosomal recessive, or X-linked ataxia. Mitochondrial dysfunction and oxidative damage have been increasingly implicated in the pathogenesis of HA. With no cure and a reduced lifespan, HA causes motor incoordination and progressive functional disabilities in young and middle-aged populations. The lack of effective therapeutic options remains a major gap in the field. Therapy aimed at boosting antioxidant defenses is efficient in the treatment of HA. The combined use of a mitochondrial antioxidant and an iron-binding chelator is rapidly emerging as a powerful therapeutic strategy for a wide range of HAs. Stem cell transplantation may represent a new avenue for clinical research in HA. Additionally, complementary and alternative medicines could play a key role in regulating cellular metabolic processes including inflammatory signaling, mitochondrial function. and lipid metabolism, therefore facilitating the process of drug development and discovery for HA. We welcome cellular models of pathology and in vivo studies that provide valuable information for all stages of biomedical research, as well as research involving human subjects in compliance with the Declaration of Helsinki.
Potential topics include, but are not limited to, the following:
- Disease-modifying management of hereditary ataxia;
- Stem cell transplantation for hereditary ataxia;
- Dysregulation of iron metabolism and mitochondrial dysfunction;
- Role of oxidative stress in hereditary ataxia;
- Future perspectives for complementary and alternative medicines.
Dr. Kah-Hui Wong
Dr. Patrícia Maciel
Dr. Piergiorgio La Rosa
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- hereditary ataxia
- movement disorder
- emerging neurotherapeutics
- complementary and alternative medicines
- secondary metabolites
- neuroprotection
- mitigation of oxidative stress
- mitochondria-targeted antioxidants
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Related Special Issue
- Emerging Therapies for Hereditary Ataxia in Cells (7 articles)
