Genetic Mechanisms of Neurological Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 20 January 2025 | Viewed by 31
Special Issue Editors
Interests: neurogenetics; neurodegeneration; neurodevelopment
Special Issues, Collections and Topics in MDPI journals
Interests: neurosciences; neurodegenerative diseases; pathologic mechanism of neurodegenerative disorders; mouse model
Special Issue Information
Dear Colleagues,
Neurological and neuropsychiatric disorders pose a considerable challenge to healthcare systems worldwide due to the absence, in a large proportion of cases, of curative or disease-altering treatments. These conditions are multifaceted and intricate in nature, with significant individual variability in the underlying genetics and biology. In addition, they are often diagnosed at stages in which nervous system involvement is already quite extensive, making recovery through therapeutic interventions quite difficult. Addressing these unmet needs in neurological and neuropsychiatric disorders may therefore require a shift in perspective, moving away from solely focusing on late-stage symptoms to targeting the preclinical and early prodromal stages. Understanding the genetic and genomic bases of neurological and neuropsychiatric diseases holds promise for the development of precision medicine approaches in these fields by offering screening solutions, enabling timely detection and diagnosis, and allowing tailored treatment strategies based on an individual’s unique clinical, genetic, and biological characteristics, as well as their exposure to environmental risk factors.
The following Special Issue is dedicated to advances in our understanding of the molecular mechanisms underlying neurological disorders, from neurodevelopmental to neurodegenerative, attained by taking advantage of genetics tools and approaches. We look forward to contributions on the identification of novel genetic causes of neurological disease, the generation of new cellular and animal models for these diseases, the dissection of molecular pathways involved in their onset and progression, the identification of novel molecular biomarkers and therapeutic targets, and the discovery and preclinical or even clinical validation of therapeutic approaches for these diseases. Original research work or review articles can be proposed.
Dr. Patrícia Maciel
Dr. Sara Duarte-Silva
Guest Editors
Manuscript Submission Information
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Keywords
- genetic mechanisms
- gene expression
- neurological disorders
- neural development
- neurodegenerative disorders
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