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Cells
Special Issues
Mechanisms of Immune Responses and Therapy
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Mechanisms of Immune Responses and Therapy

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1165

Special Issue Editors

Dr. Zhuang Wang

E-Mail Website
Guest Editor
Nationwide Children's Hospital, 575 Children's Xrd, Columbus, OH 43215, USA
Interests: immunity; autoimmunity; brain tumor; glioblastoma
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Bernhard Ryffel

E-Mail Website
Guest Editor
CNRS, INEM, UMR7355, University of Orleans, 45071 Orleans, France
Interests: injury-induced inflammation; chronic progressive respiratory diseases; viral superinfection; innate immune danger sensing; cGAS/STING; inflammasome activation; IL-1 family; Th2; Th17; altered microbiota; metabolites; tissue homeostasis; inflammatory responses; translational research in mouse models of human disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue aims to highlight recent advances in the understanding of immune cell signaling, antigen processing and presentation, cytokine-mediated regulation, tumor immune evasion, and the molecular basis of immune activation and exhaustion. Of particular interest are studies that elucidate immune regulatory pathways, the roles of immune cells across various diseases, and innovative therapeutic implications of immunomodulatory strategies.

Dr. Zhuang Wang
Prof. Dr. Bernhard Ryffel
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immunity
  • immune signaling
  • immune regulation
  • cellular immunology
  • molecular immunology
  • autoimmunity
  • immune checkpoint
  • immunotherapy

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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15 pages, 7550 KB  
Article
Novel BCR-Targeting Fusion Proteins for Antigen-Specific Depletion of Alloreactive B Cells in Antibody-Mediated Rejection
by Jing Zhang, Leiyan Wei, Lei Song, Xiaofang Lu, Liang Tan, Xin Li, Li Fu, Qizhi Luo, Xubiao Xie and Yizhou Zou
Cells 2025, 14(18), 1410; https://doi.org/10.3390/cells14181410 - 9 Sep 2025
Viewed by 285
Abstract
Donor-specific anti-HLA antibodies (DSAs) bind to donor vascular endothelial cells and mediate allograft rejection (AMR), but a clinical challenge for which targeted therapeutic options remain limited. We used a multiplexed single-antigen bead (SAB) assay to detect anti-human leukocyte antigen (HLA) antibodies. Based on [...] Read more.
Donor-specific anti-HLA antibodies (DSAs) bind to donor vascular endothelial cells and mediate allograft rejection (AMR), but a clinical challenge for which targeted therapeutic options remain limited. We used a multiplexed single-antigen bead (SAB) assay to detect anti-human leukocyte antigen (HLA) antibodies. Based on the antigens which patient’s antibodies aganist to, we developed bivalent HLA-Fc fusion proteins composed of HLA-derived antigenic domains and human IgG1-Fc effector regions (rA24-Fc and rB13-Fc). Specific binding and functional activity of the HLA-Fc proteins were further validated by flow cytometry, ELISA, complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC) assays. Our findings demonstrate that the fusion proteins rA24-Fc and rB13-Fc significantly reduced HLA-specific antibody reactivity in vitro. Notably, rA24-Fc and rB13-Fc selectively bound to B-cell hybridomas (e.g., mouse W6/32 cells) expressing membrane immunoglobulins (BCR) which bound to the most HLA class I antigens. Importantly, rA24-Fc and rB13-Fc elicited antigen-specific, Fc-dependent elimination of the specific B-cell hybridomas. This study highlights HLA-Fc fusion proteins as a promising therapeutic strategy for the antigen-specific suppression of depletion of alloreactive B cells through dual cytotoxic mechanisms. This precision targeted to BCR of B cells approach is used to apply to the treatment of antibody-mediated rejection. Full article
(This article belongs to the Special Issue Mechanisms of Immune Responses and Therapy)
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Review

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40 pages, 1058 KB  
Review
Inflammation-Driven Molecular Ageing in Chronic Inflammatory Skin Diseases: Is There a Role for Biologic Therapies?
by Klara Andrzejczak, Agata Sternak, Wiktor Witkowski and Małgorzata Ponikowska
Cells 2025, 14(18), 1442; https://doi.org/10.3390/cells14181442 - 15 Sep 2025
Viewed by 548
Abstract
Chronic inflammatory skin diseases such as atopic dermatitis, psoriasis, and hidradenitis suppurativa are systemic conditions marked by persistent immune activation. Growing evidence links them to molecular and vascular ageing, including oxidative stress, endothelial dysfunction, and reduced expression of longevity-related proteins like Klotho and [...] Read more.
Chronic inflammatory skin diseases such as atopic dermatitis, psoriasis, and hidradenitis suppurativa are systemic conditions marked by persistent immune activation. Growing evidence links them to molecular and vascular ageing, including oxidative stress, endothelial dysfunction, and reduced expression of longevity-related proteins like Klotho and SIRT1. This narrative review examines how Th17- and Th2-driven inflammation contributes to systemic inflammageing. Key cytokines—IL-17, IL-23, IL-4, IL-13, and IL-31—promote endothelial damage, oxidative stress, and metabolic dysfunction. We highlight the role of vascular biomarkers (e.g., VCAM-1, ICAM-1, ST2, P-selectin) and immune cell senescence as indicators of ageing. Finally, we explore whether biologic therapies targeting these pathways may attenuate inflammation-driven ageing. Chronic skin diseases may thus serve as accessible models of systemic inflammageing and targets for early intervention. Full article
(This article belongs to the Special Issue Mechanisms of Immune Responses and Therapy)
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