Advance in Disease Modeling and Biomarker of Neurodegenerative Disease

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Aging".

Deadline for manuscript submissions: closed (20 December 2023) | Viewed by 2787

Special Issue Editor


E-Mail Website
Guest Editor
Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheba, Israel
Interests: bipolar disorder and its treatment; the possible involvement of mitochondrial dysfunction in the etiology of neuropsychiatric diseases; mechanisms of mood stabilization; interaction among neuroinflammation, brain mitochondrial function and brain autophagy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are organizing a Special Issue entitled “Advances in Modeling and Biomarkers of Neurodegenerative Diseases” to appear in the MDPI journal Cells. We cordially invite you to contribute an original paper or a review manuscript to this Special Issue. The potential contributions will, obviously, undergo a thorough peer review process. With your contribution, we will be able to compile an up-to-date seminal and comprehensive collection which will also be considered to appear as a SI reprints book. Please find the keywords for this Special Issue and its complementary information.

Ageing is the primary risk factor for most neurodegenerative diseases., e.g., one in ten individuals aged ≥65 years has Alzheimer’s disease (AD), and its prevalence continues to increase with increasing age. Given that the populations of many of the richest countries in the world have life expectancies of over 80 years and that continue to increase, the prevalence of neurodegenerative diseases is also increasing. Since the availability of effective treatments for these diseases is scarce, if any, and since these diseases tend to progress in an irreversible manner and are associated with large socioeconomic and personal costs, the emergent need to uncover predisposition biomarkers in order to develop early interventions to prevent the occurrence of pathologies, or, at least, to slow their development, is obvious. The aim of this Special Issue is to assemble original data and reviews illustrating the plethora of models of neurodegenerative disorders and their potential biomarkers that together typify dichotomic behavioral and neurochemical characteristics of health and disease. We hope that contributions from expert groups will result in a compendium supporting researchers (and drug-developing companies) with a continuous interest in neurodegeneration and its treatment, as well as newcomers to this very important field.

With kind regards,
Dr. Galila Agam
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurodegenerative diseases
  • Alzheimer’s
  • Huntington’s
  • Parkinson’s
  • amyotrophic lateral sclerosis (ALS)
  • Friedreich ataxia
  • Lewy body disease
  • spinal muscular atrophy
  • disease models
  • mutants
  • behavior
  • disease biomarkers
  • bioinformatics

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

19 pages, 14635 KiB  
Article
A Diagnostic Gene-Expression Signature in Fibroblasts of Amyotrophic Lateral Sclerosis
by Giovanna Morello, Valentina La Cognata, Maria Guarnaccia, Vincenzo La Bella, Francesca Luisa Conforti and Sebastiano Cavallaro
Cells 2023, 12(14), 1884; https://doi.org/10.3390/cells12141884 - 18 Jul 2023
Cited by 3 | Viewed by 2396
Abstract
Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease with limited treatment options. Diagnosis can be difficult due to the heterogeneity and non-specific nature of the initial symptoms, resulting in delays that compromise prompt access to effective therapeutic strategies. Transcriptome profiling of [...] Read more.
Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease with limited treatment options. Diagnosis can be difficult due to the heterogeneity and non-specific nature of the initial symptoms, resulting in delays that compromise prompt access to effective therapeutic strategies. Transcriptome profiling of patient-derived peripheral cells represents a valuable benchmark in overcoming such challenges, providing the opportunity to identify molecular diagnostic signatures. In this study, we characterized transcriptome changes in skin fibroblasts of sporadic ALS patients (sALS) and controls and evaluated their utility as a molecular classifier for ALS diagnosis. Our analysis identified 277 differentially expressed transcripts predominantly involved in transcriptional regulation, synaptic transmission, and the inflammatory response. A support vector machine classifier based on this 277-gene signature was developed to discriminate patients with sALS from controls, showing significant predictive power in both the discovery dataset and in six independent publicly available gene expression datasets obtained from different sALS tissue/cell samples. Taken together, our findings support the utility of transcriptional signatures in peripheral cells as valuable biomarkers for the diagnosis of ALS. Full article
Show Figures

Figure 1

Back to TopTop