Molecular and Cellular Regulation of the Skeletal System in Healthy and Pathological Conditions II

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: closed (15 October 2023) | Viewed by 3011

Special Issue Editors


E-Mail Website
Guest Editor
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37128 Verona, Italy
Interests: bone degenerative diseases; cancer; transcription factors
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor Assistant
Department of Medicine, University of Verona, 37128 Verona, Italy
Interests: 3D scaffold; osteoblast; mesenchymal stem cells; microRNAs; zebrafish

Special Issue Information

Dear Colleagues,

The skeletal system is finely regulated by molecular signals throughout life. Cellular alterations involving mesenchymal stem cells or cells with bone formation and neoformation activity, such as osteoblasts, or cells with bone resorption activity, such as osteoclasts, induce bone degenerative processes. The causes of these bone alterations can be metabolic, deriving from hereditary mutations or secondary to tumor pathologies. The purpose of this second edition is, therefore, to report recent knowledge on bone, highlighting the importance of the molecular processes involved in health and pathological conditions. Papers evaluating the role of lifestyles, such as nutrition or physical activity, on bone health are also encouraged. In addition, we welcome reports of innovative models to fully understand the molecular pathways involved in skeletal changes in bone.

Dr. Maria Teresa Valenti
Guest Editor

Dr. Arianna Minoia
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone
  • degenerative diseases
  • cell signaling
  • stem cell differentiation

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Related Special Issue

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

14 pages, 962 KiB  
Review
Crosstalk between Bone and Muscles during Physical Activity
by Luca Dalle Carbonare, Arianna Minoia, Sharazed Zouari, Francesca Cristiana Piritore, Anna Vareschi, Maria Grazia Romanelli and Maria Teresa Valenti
Cells 2023, 12(16), 2088; https://doi.org/10.3390/cells12162088 - 18 Aug 2023
Cited by 7 | Viewed by 2647
Abstract
Bone–muscle crosstalk is enabled thanks to the integration of different molecular signals, and it is essential for maintaining the homeostasis of skeletal and muscle tissue. Both the skeletal system and the muscular system perform endocrine activity by producing osteokines and myokines, respectively. These [...] Read more.
Bone–muscle crosstalk is enabled thanks to the integration of different molecular signals, and it is essential for maintaining the homeostasis of skeletal and muscle tissue. Both the skeletal system and the muscular system perform endocrine activity by producing osteokines and myokines, respectively. These cytokines play a pivotal role in facilitating bone–muscle crosstalk. Moreover, recent studies have highlighted the role of non-coding RNAs in promoting crosstalk between bone and muscle in physiological or pathological conditions. Therefore, positive stimuli or pathologies that target one of the two systems can affect the other system as well, emphasizing the reciprocal influence of bone and muscle. Lifestyle and in particular physical activity influence both the bone and the muscular apparatus by acting on the single system but also by enhancing its crosstalk. Several studies have in fact demonstrated the modulation of circulating molecular factors during physical activity. These molecules are often produced by bone or muscle and are capable of activating signaling pathways involved in bone–muscle crosstalk but also of modulating the response of other cell types. Therefore, in this review we will discuss the effects of physical activity on bone and muscle cells, with particular reference to the biomolecular mechanisms that regulate their cellular interactions. Full article
Show Figures

Graphical abstract

Back to TopTop