Transcription Factors: Role in Degenerative Diseases
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (30 December 2019) | Viewed by 2717
Special Issue Editor
Interests: bone degenerative diseases; cancer; transcription factors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Degenerative diseases are serious pathological conditions with critical social outcomes. In fact, neurodegenerative diseases as well as bone and musculoskeletal disorders, cardiovascular diseases, diabetes, and cancer affect a large part of the population. Unfortunately, therapeutic approaches are not able to counteract these degenerative diseases. In fact, molecular and cellular defects causing degeneration are not completely understood and specific therapeutic targets are lacking. Among the molecules involved in degenerative diseases, transcription factors play an important role in this context. Transcription factors, by acting on gene expression, can affects cellular processes and, thereby, can induce cellular injury, leading to degenerative diseases. However, transcription factors have been ignored by the pharmaceutical industry as drug design against them has proven difficult. The possibility to identify targeted drugs with higher affinity and specificity is an important goal to prevent degenerative diseases.
In this Special Issue of Molecules, we will address the role of transcription factors in inducing cellular alterations in different degenerative diseases. Papers describing pharmaceutical approaches in this context are welcome too.
We encourage researchers to contribute experimental papers, reports, or review articles.
Dr. Maria Teresa Valenti
Guest Editor
Manuscript Submission Information
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Keywords
- Trascription factors
- Gene expression
- Degenerative diseases
- Stem cells
