Cellular Mechanisms of Therapy Resistance and Metastasis in Breast Cancer
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (20 April 2025) | Viewed by 2340
Special Issue Editors
Interests: cancer biology; genetics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Understanding the molecular mechanisms underlying therapy resistance and metastasis in breast cancer has advanced recently, offering vital new information for creating more potent treatment plans. Clarifying the molecular mechanisms underlying resistance to common treatments like chemotherapy, hormone therapy, and targeted therapies is one important area of advancement. Researchers have discovered a number of ways that cancer cells can elude therapy and persist, such as genetic mutations, epigenetic changes, and dysregulated communication pathways.
The ability to characterize diverse cell populations inside tumors and identify subpopulations with unique genetic profiles as well as potential vulnerabilities has been made possible by developments in single-cell sequencing methods. This information is essential for creating individualized treatment plans that are catered to specific patients. Furthermore, research examining the tumor microenvironment has brought attention to the function of extracellular matrix elements, cancer-associated fibroblasts, and immune cells in developing therapeutic resistance and aiding in metastasis. By focusing on these interactions, combination therapies with the goal of defeating resistance and stopping cancer from spreading may find intriguing new directions.
There is a lot of hope for overcoming drug resistance and enhancing patient outcomes with the advent of innovative therapeutic modalities, including immunotherapies and precision medicine approaches. Using such developments, researchers and clinicians are working together to decipher the biology of breast cancer and create novel therapeutic approaches that will effectively fight metastasis and resistance.
Dr. Naseem Akhter
Dr. Sajad Ahmad Dar
Guest Editors
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Keywords
- single-cell sequencing
- tumor microenvironment
- immunotherapies
- precision medicine
- therapy resistance mechanisms
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