Relationship between Inflammation and Aryl Hydrocarbon Receptor Pathway - Second Edition
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: closed (15 March 2023) | Viewed by 4884
Special Issue Editor
Interests: inflammation; aryl hydrocarbon receptor; cell physiology; cell signaling; endocrine interference; nonsteroidal anti-inflammatory drugs (NSAIDs)
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Aryl hydrocarbon Receptor (AhR) has long been known as an endogenous biosensor linking different environmental stresses to cellular homeostatic mechanisms and detoxification processes. Its evolutionary conservation and the gene sets that are responsive to this transcription factor highlight its participation in basic physiological processes such as cell growth and differentiation, and in the inflammatory response. In fact, AhR plays a central modulatory role in the immune system and is also emerging as a key player in inflammatory processes, which are triggered by several physiologic and pathologic settings in different tissues. In the last two decades, research with AhR knockout mice highlighted AhR participation in the homeostasis of almost all physiologic systems with both genomic and non-genomic mechanisms that frequently interact with inflammation pathways. In addition, the variety of endogenous and exogenous ligands that interfere with AhR signalling points out its role beyond detoxification processes and is helping in understanding its contribution in cell transition to the inflammatory state and in its resolution.
This call meets the growing need to draw a coherent framework describing the participation of AhR pathway in the management of inflammatory processes in different cell types. We will appreciate papers reporting the contribution of AhR, both in the onset and in the resolution of inflammation in physiological and pathological settings, including the recent SARS-CoV-2-induced inflammation. Evolutionary perspectives about AhR functions are also welcome.
Prof. Dr. Tiziana Guarnieri
Guest Editor
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Keywords
- aryl hydrocarbon receptor
- biosensor
- xenobiotics
- ligands
- inflammation
- immune system
- homeostasis
- cellular signalling
- evolution
