Dyskinesia in Parkinson's Disease: New Mechanisms and Molecular Targets
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".
Deadline for manuscript submissions: closed (10 March 2023) | Viewed by 24147
Special Issue Editors
Interests: Parkinson’s disease; dyskinesia; dopamine; serotonin; neurosteroids
Special Issue Information
Dear Colleagues,
L-DOPA still represents the most effective medication for alleviating motor symptoms of Parkinson’s disease. However, as the disease progresses and neuronal degeneration gets worse, the efficacy of L-DOPA is progressively reduced and motor complications, particularly L-DOPA-induced dyskinesia (LID), appear, complicating disease management.
A great contribution to the understanding of the mechanisms underlying LID has been achieved by the introduction of validated animal models of dyskinesia, mainly rodents and non-human primates. In this Special Issue, we will focus on peak-dose dyskinesia, the most troublesome type of dyskinesia, which can be reliably mimicked in such animal models.
This work aims at providing an updated overview on the mechanisms, circuits, and therapeutic approaches in dyskinesia by collecting a series of contributions from recognized international experts in this field working on either clinical or preclinical aspects.
Prof. Dr. Manolo Carta
Prof. Dr. Barbara Picconi
Guest Editors
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Keywords
- Parkinson’s disease
- L-DOPA-induced dyskinesia
- basal ganglia circuits
- motor impairments
- striatal synaptic alterations
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